A Comparison of the Effects of Fimbria-Fornix, Hippocampal, or Entorhinal Cortex Lesions on Spatial Reference and Working Memory in Rats: Short versus Long Postsurgical Recovery Period
Neurobiology of Learning and Memory. 2002-01-01; 77(1): 1-16
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1. Neurobiol Learn Mem. 2002 Jan;77(1):1-16.
A comparison of the effects of fimbria-fornix, hippocampal, or entorhinal cortex
lesions on spatial reference and working memory in rats: short versus long
postsurgical recovery period.
Galani R(1), Obis S, Coutureau E, Jarrard L, Cassel JC.
(1)Laboratoire de Neurosciences Comportementales et Cognitives, Université Louis
Pasteur, UMR 7521 ULP/CNRS, 12 rue Goethe, F-67000 Strasbourg, France.
Using a radial maze task and different postoperative recovery periods, this
experiment assessed and compared the reference and working memory performances of
adult Long-Evans male rats subjected to entorhinal cortex, fimbria-fornix, and
hippocampus lesions. Sham-operated rats were used as controls. In order to see
whether the duration of the postsurgical recovery period would influence
acquisition of the complex radial maze task, training began 1 month following
surgery (Delay 1) for half the rats in each group, while for the other half
training was started 6.5 months following surgery (Delay 2). The results
indicated that at both recovery periods the entorhinal cortex lesions failed to
affect either working or reference memory in the spatial task. Conversely, both
fimbria-fornix and hippocampus lesions impaired both reference and working
memory. While the reference memory deficit was generally similar in both
fimbria-fornix and hippocampal lesion groups, analysis of the results for working
memory indicated that at the longer delay rats with fimbria-fornix lesions were
still impaired but in animals that had the hippocampus removed, working memory
did not differ from that of controls. These results suggest that there was some
recovery in those rats with hippocampal lesions (e.g., on the working memory
task) but both hippocampal and fimbria-fornix animals were still impaired
compared to controls when training was delayed 6.5 months following the
Copyright 2002 Elsevier Science.
PMID: 11749082 [Indexed for MEDLINE]