5-HT6 receptor antagonists as treatment for age-related cognitive decline.

Anne Quiedeville, Michel Boulouard, Virginie Da Silva Costa-Aze, François Dauphin, Valentine Bouet, Thomas Freret
Reviews in the Neurosciences. 2014-01-01; 25(3):
DOI: 10.1515/revneuro-2014-0013

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1. Rev Neurosci. 2014;25(3):417-27. doi: 10.1515/revneuro-2014-0013.

5-HT6 receptor antagonists as treatment for age-related cognitive decline.

Quiedeville A, Boulouard M, Da Silva Costa-Aze V, Dauphin F, Bouet V, Freret T.

The 5-HT6 receptor (5-HT6R) is one of the most recently discovered serotonin
receptors and has received much attention after observations showing its
procognition properties. Indeed, 5-HT6R appears to be a promising target to treat
cognitive decline, particularly via its modulatory function of cholinergic and
glutamatergic systems. 5-HT6Rs are present mostly in the central nervous system,
in brain structures known to be particularly involved in memory. Growing evidence
suggests that blockade of 5-HT6R can not only improve memory processes in adult
rodents but also reverse age-related and pharmacologically induced deficits.
5-HT6R blockade could also have a beneficial effect on neuronal plasticity.
Regarding these findings, several 5-HT6R antagonists are currently going through
clinical trials. This review provides an overview of the major findings arguing
in favour of a role for 5-HT6R antagonists in developing treatment for cognitive
disorders related to ageing and neurodegenerative diseases.

DOI: 10.1515/revneuro-2014-0013
PMID: 24622786 [Indexed for MEDLINE]


Auteurs Bordeaux Neurocampus