3-D Cytoarchitectonic parcellation of human orbitofrontal cortex

Harry B.M. Uylings, Ernesto J. Sanz -Arigita, Koos de Vos, Chris W. Pool, Paul Evers, Grazyna Rajkowska
Psychiatry Research: Neuroimaging. 2010-07-01; 183(1): 1-20
DOI: 10.1016/j.pscychresns.2010.04.012

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1. Psychiatry Res. 2010 Jul 30;183(1):1-20. doi: 10.1016/j.pscychresns.2010.04.012.
Epub 2010 Jun 9.

3-D cytoarchitectonic parcellation of human orbitofrontal cortex correlation with
postmortem MRI.

Uylings HB(1), Sanz-Arigita EJ, de Vos K, Pool CW, Evers P, Rajkowska G.

Author information:
(1)Department of Anatomy & Neuroscience, VU University Medical Center, Graduate
School Neurosciences Amsterdam, Amsterdam, The Netherlands.

The orbitofrontal cortex (OFC) is located on the basal surface of the frontal
lobe and is distinguished by its unique anatomical and functional features.
Clinical and postmortem studies suggest the involvement of the orbitofrontal
cortex in psychiatric disorders. However, the exact parcellation of this cortical
region is still a matter of debate. Therefore, the goal of this study is to
provide a detailed description of the extent of borders of individual
orbitofrontal cortical areas using cytoarchitectonic criteria in a large sample
of human brains, which could be applied by independent neuroanatomists. To make
this microscopic parcellation useful to neuroimaging studies, magnetic resonance
images of postmortem brains in the coronal plane were collected prior to the
preparation of coronal histological sections from the same brains. A complete
series of coronal sections from 6 normal human brains and partial sections from
the frontal cortex of 21 normal human brains were stained with general
histological and immunohistochemical methods specific for different cell-types.
These sections were examined microscopically by two independent neuroanatomists
(HBMU and GR) to achieve reproducible delineations. After the borders were
determined, the tissue sections were superimposed on the corresponding magnetic
resonance images. Based on our cytoarchitectonical criteria, Brodmann’s areas 47
and 11 were included in the human orbitofrontal cortex. Area 47 was further
subdivided into three medial (located on the medial, anterior and posterior
orbital gyri) and two lateral (located on the lateral orbital gyrus) subareas. In
addition, we observed an anterior-posterior gradient in the cytoarchitecture of
areas 11 and 47. The transverse orbital sulcus corresponds roughly to the
transition between the subregions of the anterior and posterior OFC. Finally, the
present delineation is contrasted with an overview of the different published
nomenclatures for the OFC parcellation.

Copyright 2010 Elsevier Ireland Ltd. All rights reserved.

DOI: 10.1016/j.pscychresns.2010.04.012
PMCID: PMC2902628
PMID: 20538437 [Indexed for MEDLINE]

Auteurs Bordeaux Neurocampus