13-cis-retinoic acid suppresses hippocampal cell division and hippocampal-dependent learning in mice

J. Crandall, Y. Sakai, J. Zhang, O. Koul, Y. Mineur, W. E. Crusio, P. McCaffery
Proceedings of the National Academy of Sciences. 2004-03-29; 101(14): 5111-5116
DOI: 10.1073/pnas.0306336101

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1. Proc Natl Acad Sci U S A. 2004 Apr 6;101(14):5111-6. Epub 2004 Mar 29.

13-cis-retinoic acid suppresses hippocampal cell division and
hippocampal-dependent learning in mice.

Crandall J(1), Sakai Y, Zhang J, Koul O, Mineur Y, Crusio WE, McCaffery P.

Author information:
(1)E. K. Shriver Center, University of Massachusetts Medical School, Waltham, MA
02452, USA.

The active component of the acne drug Accutane is 13-cis-retinoic acid (RA), and
it is highly teratogenic for the developing central nervous system. Very little
is known, however, regarding the effect of this drug on the adult brain. Regions
of the brain that may be susceptible to RA are those that continue to generate
new neurons. In the adult mouse, neurogenesis is maintained in the hippocampus
and subventricular zone. This report demonstrates that a clinical dose (1
mg/kg/day) of 13-cis-RA in mice significantly reduces cell proliferation in the
hippocampus and the subventricular zone, suppresses hippocampal neurogenesis, and
severely disrupts capacity to learn a spatial radial maze task. The results
demonstrate that the regions of the adult brain where cell proliferation is
ongoing are highly sensitive to disruption by a clinical dose of 13-cis-RA.

DOI: 10.1073/pnas.0306336101
PMCID: PMC387382
PMID: 15051884 [Indexed for MEDLINE]

Auteurs Bordeaux Neurocampus