Obsessive-compulsive disorder in primary tic disorders and Gilles de la Tourette syndrome

1. Handb Clin Neurol. 2026;215:75-84. doi: 10.1016/B978-0-443-13554-5.00024-9.

Obsessive-compulsive disorder in primary tic disorders and Gilles de la Tourette
syndrome.

Worbe Y(1), Courtin E(2), Burbaud P(2).

Author information:
(1)Department of Clinical Neurophysiology, Sorbonne University, APHP-Sorbonne
University – Hospital Saint-Antoine, Paris, France; Paris Brain Institute (ICM),
Sorbonne University, Inserm U1127, CNRS UMR7225, UM75, Movement Investigation
and Therapeutics Team, Paris, France.
(2)Department of Clinical Neurophysiology, Pellegin Hospital, Bordeaux, France;
Institute for Neurodegenerative Disorders, CNRS – UMR 5293, Bordeaux, France.

This chapter provides a review of obsessive-compulsive disorder (OCD), as it
manifests in primary tic disorders and Gilles de la Tourette syndrome (GTS). We
examine the clinical features of OCD in GTS, focusing on how these symptoms
diverge from typical OCD presentations, often blending with or mimicking tics.
Key pathophysiologic mechanisms are explored, with an emphasis on the
neurobiologic substrates that underlie this unique OCD subtype and distinctions
from tics. Finally, the chapter discusses therapeutic approaches specifically
adapted for this population, highlighting both established and emerging
treatments. This chapter aims to deepen understanding of the complex interplay
between OCD and GTS, offering insights into more effective clinical management
and therapeutic strategies for affected individuals.

Copyright © 2026 Elsevier B.V. All rights reserved.

DOI: 10.1016/B978-0-443-13554-5.00024-9
PMID: 41633749 [Indexed for MEDLINE]

Auteurs Bordeaux Neurocampus