A systematic review of resting-state and task-based fmri in juvenile myoclonic epilepsy

Hossein Sanjari Moghaddam, Ali Sanjari Moghaddam, Alireza Hasanzadeh, Zahra Sanatian, Amirreza Mafi, Mohammad Hadi Aarabi, Mohammadmehdi Samimi, Vajiheh Aghamollaii, Taha Gholipour, Abbas Tafakhori
Brain Imaging and Behavior. 2021-11-17; 16(3): 1465-1494
DOI: 10.1007/s11682-021-00595-5

1. Brain Imaging Behav. 2022 Jun;16(3):1465-1494. doi:
10.1007/s11682-021-00595-5. Epub 2021 Nov 17.

A systematic review of resting-state and task-based fmri in juvenile myoclonic
epilepsy.

Sanjari Moghaddam H(1)(2)(3), Sanjari Moghaddam A(4), Hasanzadeh A(1)(2),
Sanatian Z(1), Mafi A(1)(2), Aarabi MH(5), Samimi M(1), Aghamollaii V(1),
Gholipour T(6), Tafakhori A(1).

Author information:
(1)Iranian Center of Neurological Research (ICNR), Tehran University of Medical
Sciences, Tehran, Iran.
(2)Neurology Division, School of Medicine, Tehran University of Medical
Sciences, Tehran, Iran.
(3)Radiology Division, School of Medicine, Tehran University of Medical
Sciences, Tehran, Iran.
(4)Department of Medicine, Duke University Medical Center, Durham, NC, USA.
(5)Department of Neuroscience (DNS), Padova Neuroscience Center, University of
Padova, Padua, Italy. .
(6)Department of Neurology, The George Washington University Epilepsy Center,
Washington, DC, USA.

Functional neuroimaging modalities have enhanced our understanding of juvenile
myoclonic epilepsy (JME) underlying neural mechanisms. Due to its non-invasive,
sensitive and analytical nature, functional magnetic resonance imaging (fMRI)
provides valuable insights into relevant functional brain networks and their
segregation and integration properties. We systematically reviewed the
contribution of resting-state and task-based fMRI to the current understanding
of the pathophysiology and the patterns of seizure propagation in JME
Altogether, despite some discrepancies, functional findings suggest that
corticothalamo-striato-cerebellar network along with default-mode network and
salience network are the most affected networks in patients with JME. However,
further studies are required to investigate the association between JME’s main
deficiencies, e.g., motor and cognitive deficiencies and fMRI findings.
Moreover, simultaneous electroencephalography-fMRI (EEG-fMRI) studies indicate
that alterations of these networks play a role in seizure modulation but fall
short of identifying a causal relationship between altered functional properties
and seizure propagation. This review highlights the complex pathophysiology of
JME, which necessitates the design of more personalized diagnostic and
therapeutic strategies in this group.