Central nervous system microstructural alterations in Type 1 diabetes mellitus: A systematic review of diffusion Tensor imaging studies

1. Diabetes Res Clin Pract. 2023 Nov;205:110645. doi:
10.1016/j.diabres.2023.110645. Epub 2023 Mar 31.

Central nervous system microstructural alterations in Type 1 diabetes mellitus:
A systematic review of diffusion Tensor imaging studies.

Dolatshahi M(1), Sanjari Moghaddam H(2), Saberi P(3), Mohammadi S(4), Aarabi
MH(5).

Author information:
(1)NeuroImaging Laboratories, Mallinckrodt Institute of Radiology, Washington
University School of Medicine, St. Louis, United States; NeuroImaging Network
(NIN), Universal Scientific Education and Research Network (USERN), Tehran,
Iran. Electronic address: .
(2)School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Electronic address: .
(3)School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Electronic address: .
(4)NeuroImaging Network (NIN), Universal Scientific Education and Research
Network (USERN), Tehran, Iran; School of Medicine, Tehran University of Medical
Sciences, Tehran, Iran. Electronic address: .
(5)Department of Neuroscience and Padova Neuroscience Center (PNC), University
of Padova, Padova, Italy. Electronic address: .

AIMS: Type 1 diabetes mellitus (T1DM) is a chronic childhood disease with
potentially persistent CNS disruptions. In this study, we aimed to
systematically review diffusion tensor imaging studies in patients with T1DM to
understand the microstructural effects of this entity on individuals’ brains
METHODS: We performed a systematic search and reviewed the studies to include
the DTI studies in individuals with T1DM. The data for the relevant studies were
extracted and a qualitative synthesis was performed.
RESULTS: A total of 19 studies were included, most of which showed reduced FA
widespread in optic radiation, corona radiate, and corpus callosum, as well as
other frontal, parietal, and temporal regions in the adult population, while
most of the studies in the juvenile patients showed non-significant differences
or a non-persistent pattern of changes. Also, reduced AD and MD in individuals
with T1DM compared to controls and non-significant differences in RD were noted
in the majority of studies. Microstructural alterations were associated with
clinical profile, including age, hyperglycemia, diabetic ketoacidosis and
cognitive performance.
CONCLUSION: T1DM is associated with microstructural brain alterations including
reduced FA, MD, and AD in widespread brain regions, especially in association
with glycemic fluctuations and in adult age.

Published by Elsevier B.V.

DOI: 10.1016/j.diabres.2023.110645
PMID: 37004976 [Indexed for MEDLINE]

Conflict of interest statement: Declaration of Competing Interest The authors
declare that they have no known competing financial interests or personal
relationships that could have appeared to influence the work reported in this
paper.

Auteurs Bordeaux Neurocampus