Caloric Restriction and Diet-Induced Weight Loss Do Not Induce Browning of Human Subcutaneous White Adipose Tissue in Women and Men with Obesity

Valentin Barquissau, Benjamin Léger, Diane Beuzelin, Frédéric Martins, Ez-Zoubir Amri, Didier F. Pisani, Wim H.M. Saris, Arne Astrup, Jean-José Maoret, Jason Iacovoni, Sébastien Déjean, Cédric Moro, Nathalie Viguerie, Dominique Langin
Cell Reports. 2018-01-01; 22(4): 1079-1089
DOI: 10.1016/j.celrep.2017.12.102

Barquissau V(1), Léger B(1), Beuzelin D(1), Martins F(1), Amri EZ(2), Pisani
DF(2), Saris WHM(3), Astrup A(4), Maoret JJ(1), Iacovoni J(1), Déjean S(5), Moro
C(1), Viguerie N(1), Langin D(6).

Author information:
(1)INSERM, UMR 1048, Institute of Metabolic and Cardiovascular Diseases,
Toulouse, France; University of Toulouse, Paul Sabatier University, Toulouse,
France.
(2)University of Côte d’Azur, CNRS, Inserm, iBV, Nice, France.
(3)Department of Human Biology, NUTRIM School of Nutrition and Translational
Research in Metabolism, Maastricht University Medical Centre, Maastricht, the
Netherlands.
(4)Department of Nutrition, Exercise and Sports, Faculty of Sciences, University
of Copenhagen, Copenhagen, Denmark.
(5)University of Toulouse, Paul Sabatier University, Toulouse, France; CNRS, UMR
5219, Toulouse Mathematics Institute, Toulouse, France.
(6)INSERM, UMR 1048, Institute of Metabolic and Cardiovascular Diseases,
Toulouse, France; University of Toulouse, Paul Sabatier University, Toulouse,
France; Toulouse University Hospitals, Laboratory of Clinical Biochemistry,
Toulouse, France. Electronic address: .

Comment in
Trends Endocrinol Metab. 2018 Jul;29(7):450-452. doi:
10.1016/j.tem.2018.03.004.

Caloric restriction (CR) is standard lifestyle therapy in obesity management.
CR-induced weight loss improves the metabolic profile of individuals with
obesity. In mice, occurrence of beige fat cells in white fat depots favors a
metabolically healthy phenotype, and CR promotes browning of white adipose
tissue (WAT). Here, human subcutaneous abdominal WAT samples were analyzed in
289 individuals with obesity following a two-phase dietary intervention
consisting of an 8 week very low calorie diet and a 6-month weight-maintenance
phase. Before the intervention, we show sex differences and seasonal variation,
with higher expression of brown and beige markers in women with obesity and
during winter, respectively. The very low calorie diet resulted in decreased
browning of subcutaneous abdominal WAT. During the whole dietary intervention,
evolution of body fat and insulin resistance was independent of changes in brown
and beige fat markers. These data suggest that diet-induced effects on body fat
and insulin resistance are independent of subcutaneous abdominal WAT browning in
people with obesity.

DOI: 10.1016/j.celrep.2017.12.102
PMID: 29386128 [Indexed for MEDLINE]