Concurrent measures of impulsive action and choice are partially related and differentially modulated by dopamine D1- and D2-like receptors in a rat model of impulsivity
Pharmacology Biochemistry and Behavior. 2023-01-01; 222: 173508
DOI: 10.1016/j.pbb.2022.173508
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https://www.bordeaux-neurocampus.fr/12742
1. Pharmacol Biochem Behav. 2023 Jan;222:173508. doi: 10.1016/j.pbb.2022.173508.
Epub 2022 Dec 5.
Concurrent measures of impulsive action and choice are partially related and
differentially modulated by dopamine D(1)- and D(2)-like receptors in a rat
model of impulsivity.
Bellés L(1), Arrondeau C(2), Urueña-Méndez G(3), Ginovart N(4).
Author information:
(1)Department of Psychiatry, Faculty of Medicine, University of Geneva, Rue
Michel Servet 1, CH-1211 Geneva, Switzerland; Department of Basic Neurosciences,
Faculty of Medicine, University of Geneva, Rue Michel Servet 1, CH-1211 Geneva,
Switzerland. Electronic address: .
(2)Department of Psychiatry, Faculty of Medicine, University of Geneva, Rue
Michel Servet 1, CH-1211 Geneva, Switzerland; Department of Basic Neurosciences,
Faculty of Medicine, University of Geneva, Rue Michel Servet 1, CH-1211 Geneva,
Switzerland. Electronic address: .
(3)Department of Psychiatry, Faculty of Medicine, University of Geneva, Rue
Michel Servet 1, CH-1211 Geneva, Switzerland; Department of Basic Neurosciences,
Faculty of Medicine, University of Geneva, Rue Michel Servet 1, CH-1211 Geneva,
Switzerland. Electronic address: .
(4)Department of Psychiatry, Faculty of Medicine, University of Geneva, Rue
Michel Servet 1, CH-1211 Geneva, Switzerland; Department of Basic Neurosciences,
Faculty of Medicine, University of Geneva, Rue Michel Servet 1, CH-1211 Geneva,
Switzerland. Electronic address: .
Impulsivity is a multidimensional construct, but the relationships between its
constructs and their respective underlying dopaminergic underpinnings in the
general population remain unclear. A cohort of Roman high- (RHA) and low- (RLA)
avoidance rats were tested for impulsive action and risky decision-making in the
rat gambling task, and then for delay discounting in the delay-discounting task
to concurrently measure the relationships among the three constructs of
impulsivity using a within-subject design. Then, we evaluated the effects of
dopaminergic drugs on the three constructs of impulsivity, considering innate
differences in impulsive behaviors at baseline. Risky decision-making and
delay-discounting were positively correlated, indicating that both constructs of
impulsive choice are related. Impulsive action positively correlated with risky
decision-making but not with delay discounting, suggesting partial overlap
between impulsive action and impulsive choice. RHAs showed a more impulsive
phenotype in the three constructs of impulsivity compared to RLAs, demonstrating
the comorbid nature of impulsivity in a population of rats. Amphetamine
increased impulsive action and had no effect on risky decision-making regardless
of baseline levels of impulsivity, but it decreased delay discounting only in
high impulsive RHAs. In contrast, while D1R and D3R agonism as well as D2/3R
partial agonism decreased impulsive action regardless of baseline levels of
impulsivity, D2/3R agonism decreased impulsive action exclusively in high
impulsive RHAs. Irrespective of baseline levels of impulsivity, risky
decision-making was increased by D1R and D2/3R agonism but not by D3R agonism or
D2/3R partial agonism. Finally, while D1R and D3R agonism, D2/3R partial agonism
and D2R blockade increased delay discounting irrespective of baseline levels of
impulsivity, D2/3R agonism decreased it in low impulsive RLAs only. These
findings indicate that the acute effects of dopamine drugs were partially
overlapping across dimensions of impulsivity, and that only D2/3R agonism showed
baseline-dependent effects on impulsive action and impulsive choice.
Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.
DOI: 10.1016/j.pbb.2022.173508
PMID: 36473517 [Indexed for MEDLINE]
Conflict of interest statement: Declaration of competing interest The authors
declare that there is not personal financial conflict of interest.