Sleep and schizophrenia spectrum

Christophe Gauld, Cyril Hanin
L'Encéphale. 2026-04-01; :
DOI: 10.1016/j.encep.2026.02.005

PubMed

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https://www.bordeaux-neurocampus.fr/12698

Gauld C(1), Hanin C(2).

Author information:
(1)Service de Psychopathologie du Développement, Hospices Civils de Lyon, 59,
boulevard Pinel, 69000 Lyon, France; Université Bordeaux, CNRS, SANPSY, UMR
6033, 33000 Bordeaux, France. Electronic address: .
(2)Department of Child and Adolescent Psychiatry, Centre de Référence des
Maladies Rares à Expression Psychiatrique, Pitié-Salpêtrière University
Hospital, Assistance publique-Hôpitaux de Paris, Paris, France; Groupe de
Recherche Clinique n(o) 15, Troubles Psychiatriques et Développement (PSYDEV),
Faculty of Medicine, Sorbonne Université, Paris, France.

The relationships between sleep disorders and psychotic disorders, particularly
schizophrenia, are extensively documented in the literature due to their shared
diagnostic, prognostic, and therapeutic implications. This chapter examines the
relationships between sleep medicine and schizophrenia spectrum disorders, as
well as the clinical high-risk (CHR) state. Sleep disorders such as insomnia,
restless legs syndrome, sleep apnea, and circadian rhythm disturbances can
exacerbate psychotic symptoms, negatively impacting quality of life and
treatment response. Conversely, psychotic symptoms, along with certain
treatments associated with these conditions, may worsen sleep disturbances. We
discuss the implications of early intervention in preventing progression toward
psychotic disorders, highlighting sleep as both a predictor and a potential
therapeutic target. We also present general principles for managing sleep
disturbances associated with psychotic disorders. The management of sleep in
patients with psychotic disorders requires a personalized approach, integrating
both pharmacological and non-pharmacological strategies.