Brain connectivity: complex, not chaotic
Brain Struct Funct. 2025-05-30; 230(5):
DOI: 10.1007/s00429-025-02943-3
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https://www.bordeaux-neurocampus.fr/12654
1. Brain Struct Funct. 2025 May 30;230(5):77. doi: 10.1007/s00429-025-02943-3.
Brain connectivity: complex, not chaotic.
Borra E(1), Jones DK(2), Parent M(3), Petit L(4)(5)(6), Rockland KS(7), Rushmore
RJ(8), Szczupak D(9).
Author information:
(1)Neuroscience Unit, Department of Medicine and Surgery, University of Parma,
Parma, Italy.
(2)Cardiff University Brain Research Imaging Centre (CUBRIC), Cardiff
University, Cardiff, UK.
(3)Department of Psychiatry and Neuroscience, Faculty of Medicine, Université
Laval, Quebec City, QC, Canada.
(4)Univ. Bordeaux, CNRS, IMN, UMR 5293, 33000, Bordeaux, France.
(5)IRP OpTeam, CNRS Biologie, Paris, France.
(6)Université de Sherbrooke, Sherbrooke, Canada.
(7)Department of Anatomy and Neurobiology, Chobanian and Avedisian School of
Medicine, Boston University, Boston, MA, USA. .
(8)Department of Anatomy and Neurobiology, Chobanian and Avedisian School of
Medicine, Boston University, Boston, MA, USA.
(9)Department of Neurobiology, School of Medicine, University of Pittsburgh,
Pittsburgh, PA, USA.
The term « connections » is a commonly used and convenient shorthand for
describing the complex organization of the brain, but it can easily lead to an
overemphasis on pairwise or point-to-point, source-target network connectivity.
Anatomical studies make clear that there are other important features to
consider such as divergence and collateralization (axons or bundles branching to
multiple targets), convergence (multiple bundles from different sources
converging on the same target), and scrambled topography along a trajectory.
This short « Did You Know » communication elaborates on several of these features
from the anatomical perspective, while inviting continued dialogue with the
tractography community in addressing the shared goals of better understanding
brain organization.
© 2025. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany,
part of Springer Nature.
DOI: 10.1007/s00429-025-02943-3
PMID: 40445394 [Indexed for MEDLINE]
Conflict of interest statement: Declarations. Conflict of interest: The authors
declare no competing interests.