MRI and non-MRI quantifiable neuroanatomical and functional parameters are useful for tractography
Brain Struct Funct. 2025-06-05; 230(6):
DOI: 10.1007/s00429-025-02932-6
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https://www.bordeaux-neurocampus.fr/12650
1. Brain Struct Funct. 2025 Jun 5;230(6):83. doi: 10.1007/s00429-025-02932-6.
MRI and non-MRI quantifiable neuroanatomical and functional parameters are
useful for tractography.
Schiavi S(1)(2), Borra E(3), De Luca A(4), Jones DK(5), Petit L(6)(7), Szczupak
D(8).
Author information:
(1)ASG Superconductors S.p.A, Genoa, Italy. .
(2)Department of Computer Science, University of Verona, Verona, Italy.
.
(3)Neuroscience Unit, Department of Medicine and Surgery, University of Parma,
Parma, Italy.
(4)Image Sciences Institute, University Medical Center Utrecht, Utrecht, the
Netherlands.
(5)Cardiff University Brain Research Imaging Centre (CUBRIC), Cardiff
University, Cardiff, UK.
(6)Univ. Bordeaux, CNRS, IMN, UMR 5293, Bordeaux, F-33000, France.
(7)IRP OpTeam, CNRS Biologie, France-Université de Sherbrooke, Sherbrooke,
Canada.
(8)Department of Neurobiology, University of Pittsburgh, University of
Pittsburgh, Pittsburgh, USA.
Tractography provides a powerful framework to reconstruct white matter pathways
from diffusion magnetic resonance imaging (dMRI) but remains challenged by its
inherent ambiguity and lack of direct biological specificity. This short
communication summarizes the key points of a debate held at the 2024 Tract-Anat
Retreat on the utility of MRI and non-MRI quantifiable neuroanatomical and
functional parameters for improving tractography. During the discussion,
concerns were raised about the availability of histological properties only on
post-mortem tissues, the disparity in scale between MRI and other modalities and
the additional costs (both in time and money) of such additional parameters.
However, we identified several areas that enhance the anatomical accuracy of
tractography including the potential value of histological priors, functional
imaging constraints, and microstructural metrics in guiding or validating tract
reconstructions. These perspectives underscore the need for multimodal
frameworks that bridge imaging and biology, enabling tractography towards a more
anatomically grounded representation of white matter organization.
© 2025. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany,
part of Springer Nature.
DOI: 10.1007/s00429-025-02932-6
PMID: 40471369 [Indexed for MEDLINE]
Conflict of interest statement: Declarations. Competing interests: SS is an
employee of ASG Superconductors Genoa, but this work has no commercial or
financial relationships that could be construed as a potential conflict of
interest. All the other authors have nothing to declare.