Local protein synthesis is a ubiquitous feature of neuronal pre- and postsynaptic compartments

Abstract

The regulation of synaptic proteins by posttranslational modifications and by ongoing protein synthesis and degradation drives homeostasis and plasticity at synapses. A key question is where synaptic proteins are made. Most of the neuron’s volume comprises axons and dendrites that can be micrometers or millimeters long. Thus, a substantial fraction of proteomic remodeling could potentially occur locally within both axons and dendrites. Whereas there is wealth of data indicating that protein synthesis occurs in mature dendrites, there has been much less evidence in support of local translation in mature axons.

Auteurs Bordeaux Neurocampus