Dystonia is predictive of subsequent altered dopaminergic responsiveness in a chronic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine + 3-nitropropionic acid model of striatonigral degeneration in monkeys
Neuroscience Letters. 2002-12-01; 335(1): 34-38
DOI: 10.1016/s0304-3940(02)01137-0
Lire sur PubMed
https://www.bordeaux-neurocampus.fr/12633
1. Neurosci Lett. 2002 Dec 19;335(1):34-8. doi: 10.1016/s0304-3940(02)01137-0.
Dystonia is predictive of subsequent altered dopaminergic responsiveness in a
chronic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine+3-nitropropionic acid model
of striatonigral degeneration in monkeys.
Ghorayeb I(1), Fernagut PO, Stefanova N, Wenning GK, Bioulac B, Tison F.
Author information:
(1)CNRS-UMR 5543, Université Victor Segalen Bordeaux 2, 146, rue Léo-Saignat,
33076 Bordeaux Cedex, France.
We conducted a new chronic sequential
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 3-nitropropionic acid
(3NP) intoxication paradigm in two female monkeys in order to reproduce the
striatonigral degeneration type of levodopa-unresponsive parkinsonism. A
comparison was made with MPTP-, 3NP-intoxicated and control monkeys. A
levodopa-responsive parkinsonism emerged in all MPTP-treated monkeys. During
subsequent 3NP intoxication, one of the two MPTP +3NP monkeys exhibited hindlimb
dystonia concomitantly with a reduced levodopa response. All MPTP-monkeys had
severe cell loss in the substantia nigra pars compacta (>70%), but 3NP-induced
discrete lesioned areas and cell loss predominantly in the putamen appeared only
in the dystonic and levodopa-unresponsive animal. We propose that the appearance
of dystonia after 3NP intoxication following dopaminergic striatal denervation
is the key symptom predictive of the loss of dopaminergic response.
DOI: 10.1016/s0304-3940(02)01137-0
PMID: 12457736 [Indexed for MEDLINE]