[95% CI]

Prediction of dementia risk from multimodal repeated measures: The added value of brain MRI biomarkers

Ariane Bercu, Carole Dufouil, Stéphanie Debette, Marc Joliot, Ami Tsuchida, Catherine Helmer, Anthony Devaux, Vincent Bouteloup, Cécile Proust‐Lima, Hélène Jacqmin‐Gadda
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring. 2024-04-01; 16(2):
DOI: 10.1002/dad2.12578

We evaluated whether repeated brain volumes and cSVD markers improve dementia prediction.
The 5‐year prediction of dementia is slightly improved when considering brain MRI markers.
Measures of hippocampus volume are the main MRI predictors of dementia.
Adjusted on cognition, repeated MRI has poor added value over single MRI for dementia prediction.
We utilized a longitudinal analysis that considers error‐and‐missing‐prone predictors, and competing death.