The LRRK2 G2385R Exonic Variant: A Potential Genetic Disease Modifier of Multiple System Atrophy?

Nesrine Kouki, Anne Pavy‐Le Traon, Viorica Chelban, Florian Chanquoy, Margherita Fabbri, David Bendetowicz, Henry Houlden, Lucia V. Schottlaender, Olivier Rascol, Alexandra Foubert‐Samier, Wassilios G. Meissner
Movement Disorders. 2026-02-09; :
DOI: 10.1002/mds.70219

1. Mov Disord. 2026 Feb 9. doi: 10.1002/mds.70219. Online ahead of print.

The LRRK2 G2385R Exonic Variant: A Potential Genetic Disease Modifier of
Multiple System Atrophy?

Kouki N(1), Pavy-Le Traon A(2)(3), Chelban V(4)(5), Chanquoy F(6), Fabbri
M(2)(3)(7), Bendetowicz D(1)(8), Houlden H(4), Schottlaender LV(4)(9)(10),
Rascol O(2)(3)(7), Foubert-Samier A(1)(8), Meissner WG(1)(8)(11).

Author information:
(1)CHU de Bordeaux, Service de Neurologie des Maladies Neurodégénératives, IMNc,
CRMR AMS, NS-Park/FCRIN Network, Bordeaux, France.
(2)Clinical Investigation Center CIC1436, Department of Clinical Pharmacology
and Neurosciences, Parkinson Expert Centre and NeuroToul Center of Excellence in
Neurodegeneration of Toulouse, INSERM, University of Toulouse, CHU of Toulouse,
Toulouse, France.
(3)MSA French Reference Center, University Hospital Toulouse, Toulouse, France.
(4)The National Hospital for Neurology and Neurosurgery, Department of
Neuromuscular Diseases, University College London Queen Square Institute of
Neurology, London, United Kingdom.
(5)Neurobiology and Medical Genetics Laboratory, ‘Nicolae Testemitanu’ State
University of Medicine and Pharmacy, Chisinau, Republic of Moldova.
(6)Pôle des Neurosciences Cliniques, CHU de Bordeaux, Bordeaux, France.
(7)ToNIC, Toulouse NeuroImaging Center, Université de Toulouse, Inserm, UPS,
Toulouse, France.
(8)Univ. de Bordeaux, CNRS, IMN, UMR 5293, Bordeaux, France.
(9)Instituto de Investigaciones en Medicina Traslacional, CONICET-Universidad
Austral, Pilar, Argentina.
(10)Instituto de medicina genómica, Hospital Universitario Austral, Universidad
Austral, Pilar, Argentina.
(11)Department of Medicine, University of Otago, and the New Zealand Brain
Research Institute, Christchurch, New Zealand.