Subacute systemic 3-nitropropionic acid intoxication induces a distinct motor disorder in adult C57Bl/6 mice: behavioural and histopathological characterisation

P.O. Fernagut, E. Diguet, N. Stefanova, M. Biran, G.K. Wenning, P. Canioni, B. Bioulac, F. Tison
Neuroscience. 2002-11-01; 114(4): 1005-1017
DOI: 10.1016/s0306-4522(02)00205-1

1. Neuroscience. 2002;114(4):1005-17. doi: 10.1016/s0306-4522(02)00205-1.

Subacute systemic 3-nitropropionic acid intoxication induces a distinct motor
disorder in adult C57Bl/6 mice: behavioural and histopathological
characterisation.

Fernagut PO(1), Diguet E, Stefanova N, Biran M, Wenning GK, Canioni P, Bioulac
B, Tison F.

Author information:
(1)Laboratoire de Neurophysiologie, Physiologie et Physiopathologie de la
Signalisation Cellulaire, UMR-CNRS 5543, Université Victor Segalen, Bordeaux 2,
146 rue Léo Saignat, 33076 Bordeaux Cedex, France.

Data on motor behavioural disorders induced by systemic 3-nitropropionic acid,
an irreversible inhibitor of mitochondrial succinate dehydrogenase and their
histopathological correlates in mice, are sparse. We thus further characterised
the subacute 3-nitropropionic-acid-induced motor disorder and its time course in
C57Bl/6 mice using standard behavioural tests, histopathological correlates and
in vivo magnetic resonance imaging. Firstly, we studied two intoxication
paradigms (340 and 560 mg 3-nitropropionic acid/kg, 7 days) compared to
controls. The low-dose regimen induced only slight motor changes (reduced
hindlimb stride length and rearing). The high-dose regimen induced significant
(P