Neuropathological and behavioral changes induced by various treatment paradigms with MPTP and 3-nitropropionic acid in mice: towards a model of striatonigral degeneration (multiple system atrophy)
Acta Neuropathologica. 2003-08-01; 106(2): 157-166
DOI: 10.1007/s00401-003-0717-y
Stefanova N(1), Puschban Z, Fernagut PO, Brouillet E, Tison F, Reindl M,
Jellinger KA, Poewe W, Wenning GK.
Author information:
(1)Department of Neurology, University Hospital of Innsbruck, Anichstrasse 35,
6020 Innsbruck, Austria.
We characterized two models of dual nigral and striatal lesions replicating the
lesion pattern of striatonigral degeneration, the neuropathological hallmark of
parkinsonism associated with multiple system atrophy (SND/MSA-P). For this
purpose, we used systemic administration of 1-methyl-4-phenyl-1, 2, 3,
6-tetrahydropyridine (MPTP) and 3-nitropropionic acid (3-NP) in C57BL mice. One
group of animals was first injected with MPTP followed by 3NP (MPTP+3-NP model).
In the second group 3-NP was injected first, followed by MPTP (3-NP+MPTP model).
The behavioral and neuropathological characteristics of these two models were
compared to those observed after single 3-NP or MPTP intoxication. Results
showed that, compared to control mice, spontaneous nocturnal locomotor activity
was preserved in the MPTP+3-NP model, whereas it was reduced by 27% ( P