Decreased Cortical Thickness in the Anterior Cingulate Cortex in Adults with Autism.
J Autism Dev Disord. 2018-12-03; 49(4): 1402-1409
DOI: 10.1007/s10803-018-3807-3
Lire sur PubMed
https://www.bordeaux-neurocampus.fr/12495
1. J Autism Dev Disord. 2019 Apr;49(4):1402-1409. doi: 10.1007/s10803-018-3807-3.
Decreased Cortical Thickness in the Anterior Cingulate Cortex in Adults with
Autism.
Laidi C(1)(2)(3)(4), Boisgontier J(5)(6)(7), de Pierrefeu A(8), Duchesnay E(8),
Hotier S(5)(6)(7)(9), d’Albis MA(5)(6)(7)(9), Delorme R(7)(10)(11), Bolognani
F(12), Czech C(12), Bouquet C(12), Amestoy A(13), Petit J(10), Holiga Š(12),
Dukart J(12), Gaman A(5)(7)(9), Toledano E(14), Ly-Le Moal M(14), Scheid
I(5)(7)(9), Leboyer M(5)(7)(9), Houenou J(5)(6)(7)(9).
Author information:
(1)Institut National de la Santé et de la Recherche Médicale (INSERM), U955,
Institut Mondor de Recherche Biomédicale, Psychiatrie Translationnelle (Créteil,
France), 51 Avenue du Maréchal de Lattre de Tassigny, 94010, Créteil, France.
.
(2)UNIACT, NeuroSpin, CEA, Université Paris-Saclay, Paris, France.
.
(3)Centre expert (Asperger), Fondation Fondamental, Créteil, France.
.
(4)Pôle de Psychiatrie, Assistance Publique-Hôpitaux de Paris (AP-HP), Faculté
de Médecine de Créteil, DHU PePsy, Hôpitaux Universitaires Mondor, 51 Avenue du
Maréchal de Lattre de Tassigny, 94010, Créteil, France. .
(5)Institut National de la Santé et de la Recherche Médicale (INSERM), U955,
Institut Mondor de Recherche Biomédicale, Psychiatrie Translationnelle (Créteil,
France), 51 Avenue du Maréchal de Lattre de Tassigny, 94010, Créteil, France.
(6)UNIACT, NeuroSpin, CEA, Université Paris-Saclay, Paris, France.
(7)Centre expert (Asperger), Fondation Fondamental, Créteil, France.
(8)NeuroSpin, CEA, Université Paris-Saclay, Paris, France.
(9)Pôle de Psychiatrie, Assistance Publique-Hôpitaux de Paris (AP-HP), Faculté
de Médecine de Créteil, DHU PePsy, Hôpitaux Universitaires Mondor, 51 Avenue du
Maréchal de Lattre de Tassigny, 94010, Créteil, France.
(10)Service de psychiatrie de l’enfant et de l’adolescent, Assistance
Publique-Hôpitaux de Paris (AP-HP), Hôpital Robert Debré, 48 boulevard Sérurier,
75019, Paris, France.
(11)Institut Pasteur, Human Genetics and Cognitive Functions Unit, 25-28 Rue du
Dr Roux, 75015, Paris, France.
(12)Neuroscience, Ophthalmology, and Rare Diseases (NORD), Roche Pharma Research
and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd.,
Grenzacherstrasse 124, 4070, Basel, Switzerland.
(13)Charles Perrens Hospital, Autism Expert Center, 121 rue de la Bechade,
Bordeaux, France.
(14)Institut Roche, 30 cours de l’Ile Seguin, 92650, Boulogne-Billancourt cedex,
France.
Autism spectrum disorder (ASD) is a developmental disorder underdiagnosed in
adults. To date, no consistent evidence of alterations in brain structure has
been reported in adults with ASD and few studies were conducted at that age. We
analyzed structural magnetic resonance imaging data from 167 high functioning
adults with ASD and 195 controls. We ran our analyses on a discovery (n = 301)
and a replication sample (n = 61). The right caudal anterior cingulate cortical
thickness was significantly thinner in adults with ASD compared to controls in
both the discovery and the replication sample. Our work underlines the relevance
of studying the brain anatomy of an adult ASD population.
DOI: 10.1007/s10803-018-3807-3
PMID: 30511125 [Indexed for MEDLINE]