Persistence of dysfunctional natural killer cells in adults with high-functioning autism spectrum disorders: stigma/consequence of unresolved early infectious events?
Molecular Autism. 2019-05-15; 10(1):
DOI: 10.1186/s13229-019-0269-1
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https://www.bordeaux-neurocampus.fr/12493
1. Mol Autism. 2019 May 15;10:22. doi: 10.1186/s13229-019-0269-1. eCollection
2019.
Persistence of dysfunctional natural killer cells in adults with
high-functioning autism spectrum disorders: stigma/consequence of unresolved
early infectious events?
Bennabi M(#)(1)(2)(3), Tarantino N(#)(4), Gaman A(2)(3), Scheid I(2)(3),
Krishnamoorthy R(1), Debré P(4), Bouleau A(3), Caralp M(5)(6), Gueguen S(5)(6),
Le-Moal ML(7), Bouvard M(2)(8), Amestoy A(2)(8), Delorme R(2)(9), Leboyer
M(#)(2)(3), Tamouza R(#)(1)(2)(3), Vieillard V(#)(4).
Author information:
(1)1INSERM, U1160, Hôpital Saint Louis, Paris, France.
(2)2Fondation FondaMental, Créteil, France.
(3)4DHU PePSY, Department of psychiatry, Mondor Hospital, Université Paris Est
Créteil, INSERM, U955, Psychiatrie Translationnelle, Créteil, France.
(4)3Sorbonne Université, UPMC, INSERM U1135, CNRS ERL8255, Centre d’Immunologie
et des Maladies Infectieuses (CIMI-Paris), Paris, France.
(5)5Inserm Transfer, Paris, France.
(6)6French Institute of Health and Medical Research, Paris, France.
(7)Institut Roche, Boulogne-Billancourt, France.
(8)Institut de Neurosciences Cognitives et Intégratives d’Aquitaine, Université
de Bordeaux, Bordeaux, France.
(9)DHU Protect, Service de Psychiatrie de l’Enfant et de l’Adolescent, Hôpital
Robert Debré, Département de Génétique Humaine et Fonctions Cognitives, Institut
Pasteur, Paris, France.
(#)Contributed equally
BACKGROUND: Autism spectrum disorders (ASD) are characterized by abnormal
neurodevelopment, genetic, and environmental risk factors, as well as immune
dysfunctions. Several lines of evidence suggest alterations in innate immune
responses in children with ASD. To address this question in adults with
high-functioning ASD (hf-ASD), we sought to investigate the role of natural
killer (NK) cells in the persistence of ASD.
METHODS: NK cells from 35 adults with hf-ASD were compared to that of 35 healthy
controls (HC), selected for the absence of any immune dysfunctions, at different
time-points, and over a 2-year follow-up period for four patients. The phenotype
and polyfunctional capacities of NK cells were explored according to infectious
stigma and clinical parameters (IQ, social, and communication scores).
RESULTS: As compared to HC, NK cells from patients with hf-ASD showed a high
level of cell activation (p