Neurophotonic tools for microscopic measurements and manipulation: status report
Neurophoton.. 2022-04-27; 9(S1):
DOI: 10.1117/1.nph.9.s1.013001
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https://www.bordeaux-neurocampus.fr/12439
Abdelfattah AS(1), Ahuja S(2)(3), Akkin T(4), Allu SR(2)(3), Brake J(5), Boas
DA(6), Buckley EM(7)(8), Campbell RE(9)(10), Chen AI(6), Cheng X(6), Čižmár
T(11), Costantini I(12)(13), De Vittorio M(14), Devor A(6)(15), Doran PR(6), El
Khatib M(2)(3), Emiliani V(16), Fomin-Thunemann N(6), Fainman Y(17),
Fernandez-Alfonso T(18), Ferri CGL(19), Gilad A(20), Han X(6), Harris A(21),
Hillman EMC(22), Hochgeschwender U(23), Holt MG(24), Ji N(25), Kılıç K(6), Lake
EMR(26), Li L(27), Li T(4), Mächler P(6), Miller EW(28), Mesquita RC(29),
Nadella KMNS(18), Nägerl UV(30), Nasu Y(9), Nimmerjahn A(31), Ondráčková P(11),
Pavone FS(13)(32), Perez Campos C(22), Peterka DS(22), Pisano F(14), Pisanello
F(14), Puppo F(19), Sabatini BL(33), Sadegh S(19), Sakadzic S(15), Shoham S(34),
Shroff SN(6), Silver RA(18), Sims RR(16), Smith SL(35), Srinivasan VJ(36),
Thunemann M(6), Tian L(37), Tian L(38), Troxler T(2)(3), Valera A(18), Vaziri
A(39)(40), Vinogradov SA(2)(3), Vitale F(41), Wang LV(27), Uhlířová H(11), Xu
C(42), Yang C(43), Yang MH(17), Yellen G(44), Yizhar O(21), Zhao Y(45).
Author information:
(1)Brown University, Department of Neuroscience, Providence, Rhode Island,
United States.
(2)University of Pennsylvania, Perelman School of Medicine, Department of
Biochemistry and Biophysics, Philadelphia, Pennsylvania, United States.
(3)University of Pennsylvania, School of Arts and Sciences, Department of
Chemistry, Philadelphia, Pennsylvania, United States.
(4)University of Minnesota, Department of Biomedical Engineering, Minneapolis,
Minnesota, United States.
(5)Harvey Mudd College, Department of Engineering, Claremont, California, United
States.
(6)Boston University, Department of Biomedical Engineering, Boston,
Massachusetts, United States.
(7)Georgia Institute of Technology and Emory University, Wallace H. Coulter
Department of Biomedical Engineering, Atlanta, Georgia, United States.
(8)Emory University, Department of Pediatrics, Atlanta, Georgia, United States.
(9)University of Tokyo, Department of Chemistry, Tokyo, Japan.
(10)University of Alberta, Department of Chemistry, Edmonton, Alberta, Canada.
(11)Institute of Scientific Instruments of the Czech Academy of Sciences, Brno,
Czech Republic.
(12)University of Florence, European Laboratory for Non-Linear Spectroscopy,
Department of Biology, Florence, Italy.
(13)National Institute of Optics, National Research Council, Rome, Italy.
(14)Istituto Italiano di Tecnologia, Center for Biomolecular Nanotechnologies,
Arnesano, Italy.
(15)Massachusetts General Hospital, Harvard Medical School, Athinoula A.
Martinos Center for Biomedical Imaging, Charlestown, Massachusetts, United
States.
(16)Sorbonne University, INSERM, CNRS, Institut de la Vision, Paris, France.
(17)University of California San Diego, Department of Electrical and Computer
Engineering, La Jolla, California, United States.
(18)University College London, Department of Neuroscience, Physiology and
Pharmacology, London, United Kingdom.
(19)University of California San Diego, Departments of Neurosciences, La Jolla,
California, United States.
(20)The Hebrew University of Jerusalem, Institute for Medical Research
Israel-Canada, Department of Medical Neurobiology, Faculty of Medicine,
Jerusalem, Israel.
(21)Weizmann Institute of Science, Department of Brain Sciences, Rehovot,
Israel.
(22)Columbia University, Zuckerman Mind Brain Behavior Institute, New York,
United States.
(23)Central Michigan University, Department of Neuroscience, Mount Pleasant,
Michigan, United States.
(24)University of Porto, Instituto de Investigação e Inovação em Saúde (i3S),
Porto, Portugal.
(25)University of California Berkeley, Department of Physics, Berkeley,
California, United States.
(26)Yale School of Medicine, Department of Radiology and Biomedical Imaging, New
Haven, Connecticut, United States.
(27)California Institute of Technology, Andrew and Peggy Cherng Department of
Medical Engineering, Department of Electrical Engineering, Pasadena, California,
United States.
(28)University of California Berkeley, Departments of Chemistry and Molecular &
Cell Biology and Helen Wills Neuroscience Institute, Berkeley, California,
United States.
(29)University of Campinas, Institute of Physics, Campinas, São Paulo, Brazil.
(30)Interdisciplinary Institute for Neuroscience University of Bordeaux & CNRS,
Bordeaux, France.
(31)Salk Institute for Biological Studies, Waitt Advanced Biophotonics Center,
La Jolla, California, United States.
(32)University of Florence, European Laboratory for Non-Linear Spectroscopy,
Department of Physics, Florence, Italy.
(33)Harvard Medical School, Howard Hughes Medical Institute, Department of
Neurobiology, Boston, Massachusetts, United States.
(34)New York University Grossman School of Medicine, Tech4Health and
Neuroscience Institutes, New York, New York, United States.
(35)University of California Santa Barbara, Department of Electrical and
Computer Engineering, Santa Barbara, California, United States.
(36)New York University Langone Health, Departments of Ophthalmology and
Radiology, New York, New York, United States.
(37)Boston University, Departments of Electrical Engineering and Biomedical
Engineering, Boston, Massachusetts, United States.
(38)University of California Davis, Department of Biochemistry and Molecular
Medicine, Davis, California, United States.
(39)Rockefeller University, Laboratory of Neurotechnology and Biophysics, New
York, New York, United States.
(40)The Rockefeller University, The Kavli Neural Systems Institute, New York,
New York, United States.
(41)Center for Neuroengineering and Therapeutics, Departments of Neurology,
Bioengineering, Physical Medicine and Rehabilitation, Philadelphia,
Pennsylvania, United States.
(42)Cornell University, School of Applied and Engineering Physics, Ithaca, New
York, United States.
(43)California Institute of Technology, Departments of Electrical Engineering,
Bioengineering and Medical Engineering, Pasadena, California, United States.
(44)Harvard Medical School, Department of Neurobiology, Boston, Massachusetts,
United States.
(45)Carnegie Mellon University, Department of Biological Sciences, Pittsburgh,
Pennsylvania, United States.
Neurophotonics was launched in 2014 coinciding with the launch of the BRAIN
Initiative focused on development of technologies for advancement of
neuroscience. For the last seven years, Neurophotonics’ agenda has been well
aligned with this focus on neurotechnologies featuring new optical methods and
tools applicable to brain studies. While the BRAIN Initiative 2.0 is pivoting
towards applications of these novel tools in the quest to understand the brain,
this status report reviews an extensive and diverse toolkit of novel methods to
explore brain function that have emerged from the BRAIN Initiative and related
large-scale efforts for measurement and manipulation of brain structure and
function. Here, we focus on neurophotonic tools mostly applicable to animal
studies. A companion report, scheduled to appear later this year, will cover
diffuse optical imaging methods applicable to noninvasive human studies. For
each domain, we outline the current state-of-the-art of the respective
technologies, identify the areas where innovation is needed, and provide an
outlook for the future directions.
© 2022 The Authors.
DOI: 10.1117/1.NPh.9.S1.013001
PMCID: PMC9047450
PMID: 35493335