A roadmap towards standardized neuroimaging approaches for human thalamic nuclei
Nat. Rev. Neurosci.. 2024-10-17; 25(12): 792-808
DOI: 10.1038/s41583-024-00867-1
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https://www.bordeaux-neurocampus.fr/12334
Segobin S(1), Haast RAM(2)(3), Kumar VJ(4), Lella A(5), Alkemade A(6), Bach
Cuadra M(7)(8), Barbeau EJ(9), Felician O(10), Pergola G(5)(11)(12), Pitel
AL(13), Saranathan M(14), Tourdias T(15)(16), Hornberger M(17).
Author information:
(1)Normandie University, UNICAEN, PSL Université Paris, EPHE, INSERM, U1077, CHU
de Caen, Cyceron, Neuropsychologie et Imagerie de la Mémoire Humaine, Caen,
France. .
(2)Aix-Marseille University, CRMBM CNRS UMR 7339, Marseille, France.
(3)APHM, La Timone Hospital, CEMEREM, Marseille, France.
(4)Max Planck Institute for Biological Cybernetics, Tuebingen, Germany.
(5)Department of Translational Biomedicine and Neuroscience (DiBraiN),
University of Bari Aldo Moro, Bari, Italy.
(6)Integrative Model-based Cognitive Neuroscience Unit, Department of
Psychology, University of Amsterdam, Amsterdam, The Netherlands.
(7)CIBM Center for Biomedical Imaging, Lausanne, Switzerland.
(8)Radiology Department, Lausanne University and University Hospital, Lausanne,
Switzerland.
(9)Centre de recherche Cerveau et Cognition (Cerco), UMR5549, CNRS – Université
de Toulouse, Toulouse, France.
(10)Aix Marseille Université, INSERM INS UMR 1106, APHM, Marseille, France.
(11)Lieber Institute for Brain Development, Johns Hopkins Medical Campus,
Baltimore, MD, USA.
(12)Department of Psychiatry and Behavioral Sciences, Johns Hopkins University
School of Medicine, Baltimore, MD, USA.
(13)Normandie University, UNICAEN, INSERM, U1237, PhIND « Physiopathology and
Imaging of Neurological Disorders », NeuroPresage Team, Cyceron, Caen, France.
(14)Department of Radiology, UMass Chan Medical School, Worcester, MA, USA.
(15)Neuroimagerie diagnostique et thérapeutique, CHU de Bordeaux, Bordeaux,
France.
(16)Neurocentre Magendie, University of Bordeaux, INSERM U1215, Bordeaux,
France.
(17)Norwich Medical School, University of East Anglia, Norwich, UK.
.
The thalamus has a key role in mediating cortical-subcortical interactions but
is often neglected in neuroimaging studies, which mostly focus on changes in
cortical structure and activity. One of the main reasons for the thalamus being
overlooked is that the delineation of individual thalamic nuclei via
neuroimaging remains controversial. Indeed, neuroimaging atlases vary
substantially regarding which thalamic nuclei are included and how their
delineations were established. Here, we review current and emerging methods for
thalamic nuclei segmentation in neuroimaging data and consider the limitations
of existing techniques in terms of their research and clinical applicability. We
address these challenges by proposing a roadmap to improve thalamic nuclei
segmentation in human neuroimaging and, in turn, harmonize research approaches
and advance clinical applications. We believe that a collective effort is
required to achieve this. We hope that this will ultimately lead to the thalamic
nuclei being regarded as key brain regions in their own right and not (as often
currently assumed) as simply a gateway between cortical and subcortical regions.
© 2024. Springer Nature Limited.
DOI: 10.1038/s41583-024-00867-1
PMID: 39420114 [Indexed for MEDLINE]
Conflict of interest statement: Competing interests The authors declare no
competing interests.