Stimulation magnétique transcrânienne dans la douleur neuropathique avec dépression comorbide : revue narrative
L'Encéphale. 2026-02-01; 52(1): 77-86
DOI: 10.1016/j.encep.2025.05.008
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https://www.bordeaux-neurocampus.fr/12117
1. Encephale. 2026 Feb;52(1):77-86. doi: 10.1016/j.encep.2025.05.008. Epub 2025
Sep 9.
[Impact of transcranial magnetic stimulation on depressive symptoms relief in
patients with chronic neuropathic pain and comorbid depression: A narrative
literature review].
[Article in French]
Durade-Replat PE(1), Floccia M(2), Philippe A(2), Bienvenu TCM(3).
Author information:
(1)Centre d’évaluation et de traitement de la douleur, CHU de Bordeaux,
Bordeaux, France; Centre de référence régional des pathologies anxieuses et de
la dépression, pôle de psychiatrie générale et universitaire, centre hospitalier
Charles-Perrens, 33076 Bordeaux, France. Electronic address:
.
(2)Centre d’évaluation et de traitement de la douleur, CHU de Bordeaux,
Bordeaux, France.
(3)Centre de référence régional des pathologies anxieuses et de la dépression,
pôle de psychiatrie générale et universitaire, centre hospitalier
Charles-Perrens, 33076 Bordeaux, France; Inserm U1215, Neurocentre Magendie,
33000 Bordeaux, France. Electronic address: .
Neuropathic pain results from an injury or a dysfunction of the somatosensory
system. Management of this disease is complex due to a restricted therapeutic
arsenal and limited efficacy of currently available treatments. Because of its
chronic and disabling nature, neuropathic pain is strongly associated with
depressive disorders. New neuromodulatory approaches such as repetitive
transcranial magnetic stimulation (rTMS) represent an innovative therapeutic
option with documented efficacy in the treatment of neuropathic pain and major
depressive disorder respectively. Despite the frequent comorbidity between
neuropathic pain and depressive disorder, there is no accurate data in the
literature concerning the place of rTMS in the combined treatment of these two
diseases. This narrative literature review was conducted to assess the impact of
antalgic rTMS protocols on the improvement of depressive symptoms in patients
with chronic neuropathic pain. An analysis of 20 trials showed that motor cortex
rTMS protocols with optimised parameters (frequency of at least 10 Hz, at least
2000 pulses per session and at least 10 stimulation sessions) could improve
depressive symptoms in patients with chronic neuropathic pain. Other cortical
target protocols including dorsolateral prefrontal cortex, anterior cingulate
cortex and secondary somatosensory cortex did not seem to be effective in
relieving depressive symptoms in these patients. Available data indicates a
strong heterogeneity and must be confirmed by large sample size randomized
trials.
Copyright © 2025 L’Encéphale, Paris. Published by Elsevier Masson SAS. All
rights reserved.
DOI: 10.1016/j.encep.2025.05.008
PMID: 40930915 [Indexed for MEDLINE]
Conflict of interest statement: Déclaration de liens d’intérêts Les auteurs
déclarent ne pas avoir de liens d’intérêts.