Maternal dietary omega-3 deficiency worsens the deleterious effects of prenatal inflammation on the gut-brain axis in the offspring across lifetime.

1. Neuropsychopharmacology. 2021 Feb;46(3):579-602. doi:
10.1038/s41386-020-00793-7. Epub 2020 Aug 11.

Maternal dietary omega-3 deficiency worsens the deleterious effects of prenatal
inflammation on the gut-brain axis in the offspring across lifetime.

Leyrolle Q(1)(2), Decoeur F(1), Briere G(1)(3), Amadieu C(1), Quadros ARAA(1),
Voytyuk I(1), Lacabanne C(1), Benmamar-Badel A(1), Bourel J(1), Aubert A(1),
Sere A(1), Chain F(4), Schwendimann L(2), Matrot B(2), Bourgeois T(2), Grégoire
S(5), Leblanc JG(6), De Moreno De Leblanc A(6), Langella P(4), Fernandes GR(7),
Bretillon L(5), Joffre C(1), Uricaru R(3), Thebault P(3), Gressens P(2)(8),
Chatel JM(4), Layé S(9), Nadjar A(10).

Author information:
(1)University Bordeaux, INRAE, Bordeaux INP, NutriNeuro, UMR 1286, F-33000,
Bordeaux, France.
(2)Université de Paris, NeuroDiderot, Inserm, F-75019, Paris, France.
(3)CNRS, Bordeaux INP, LaBRI, UMR 5800, F-33400, Talence, France.
(4)Micalis Institute, INRAE, AgroParisTech, Université Paris-Saclay, 78350,
Jouy-en-Josas, France.
(5)Centre des Sciences du Goût et de l’Alimentation, AgroSup Dijon, CNRS, INRAE,
Université Bourgogne Franche-Comté, Dijon, France.
(6)CERELA-CONICET, San Miguel de Tucuman, 4000, Tucuman, Argentina.
(7)Rene Rachou Institute – Oswaldo Cruz Foundation, Belo Horizonte, MG, Brazil.
(8)Centre for the Developing Brain, Department of Division of Imaging Sciences
and Biomedical Engineering, King’s College London, King’s Health Partners, St.
Thomas’ Hospital, London, SE1 7EH, UK.
(9)University Bordeaux, INRAE, Bordeaux INP, NutriNeuro, UMR 1286, F-33000,
Bordeaux, France. .
(10)University Bordeaux, INRAE, Bordeaux INP, NutriNeuro, UMR 1286, F-33000,
Bordeaux, France. .

Maternal immune activation (MIA) and poor maternal nutritional habits are risk
factors for the occurrence of neurodevelopmental disorders (NDD). Human studies
show the deleterious impact of prenatal inflammation and low n-3 polyunsaturated
fatty acid (PUFA) intake on neurodevelopment with long-lasting consequences on
behavior. However, the mechanisms linking maternal nutritional status to MIA are
still unclear, despite their relevance to the etiology of NDD. We demonstrate
here that low maternal n-3 PUFA intake worsens MIA-induced early gut
dysfunction, including modification of gut microbiota composition and higher
local inflammatory reactivity. These deficits correlate with alterations of
microglia-neuron crosstalk pathways and have long-lasting effects, both at
transcriptional and behavioral levels. This work highlights the perinatal period
as a critical time window, especially regarding the role of the gut-brain axis
in neurodevelopment, elucidating the link between MIA, poor nutritional habits,
and NDD.

DOI: 10.1038/s41386-020-00793-7
PMCID: PMC8026603
PMID: 32781459 [Indexed for MEDLINE]

Auteurs Bordeaux Neurocampus