Position paper: leveraging non-human primate (NHP) specificities to accelerate Parkinson’s disease and ageing research
npj Parkinsons Dis.. 2025-08-02; 11(1):
DOI: 10.1038/s41531-025-01088-8
Lire sur PubMed
https://www.bordeaux-neurocampus.fr/11934
Bezard E(1), Anderson RM(2), Badin RA(3), Bergman H(4), Boehringer A(5),
Borgognon S(6)(7), Emborg ME(8)(9), Kordower JH(5), Li JY(10)(11), Martel
AC(12), Metzger JM(8), Smith Y(12), Takada M(13), Takahashi J(14), Takahashi
R(15), Dehay B(16).
Author information:
(1)Univ. Bordeaux, CNRS, IMN, UMR 5293, F-33000, Bordeaux, France.
.
(2)Division of Geriatrics, Department of Medicine, SMPH, University of
Wisconsin-Madison, & GRECC, William S Middleton Memorial Veterans Hospital,
Madison, WI, USA.
(3)Commissariat à l’Energie Atomique (CEA), Molecular Imaging Research Center
(MIRCen), Fontenay-aux-Roses, France.
(4)The Edmond and Lily Safra Center for Brain Science, The Hebrew University,
Jerusalem, Israel.
(5)ASU-Banner Neurodegenerative Disease Research Center, Arizona State
University, Tempe, AZ, 85281, USA.
(6)Department of Neurosciences and Movement Sciences, University of Fribourg,
Fribourg, Switzerland.
(7)Center for the Neural Basis of Cognition, Department of Bioengineering,
University of Pittsburgh, Pittsburgh, PA, 15261, USA.
(8)Preclinical Parkinson’s Research Program, Wisconsin National Primate Research
Center, University of Wisconsin-Madison, Madison, WI, 53715, USA.
(9)Department of Medical Physics, University of Wisconsin-Madison, Madison, WI,
53715, USA.
(10)Laboratory of Research in Parkinson’s Disease and Related Disorders, Health
Sciences Institute, China Medical University, Shenyang, China.
(11)Neural Plasticity and Repair Unit, Department of Experimental Medical
Science, Lund University, Lund, Sweden.
(12)Department of Neurology, Emory National Primate Research Center, Emory
University, 954, Gatewood Rd NE, Atlanta, GA, 30329, USA.
(13)Department of Neurology, Graduate School of Medicine, Osaka University,
Suita, Osaka, 565-0871, Japan.
(14)Department of Clinical Application, Center for iPS Cell Research and
Application, Kyoto University, Kyoto, Japan.
(15)Kyoto University Office of Research Acceleration (KURA), Kyoto, 606-8501,
Japan.
(16)Univ. Bordeaux, CNRS, IMN, UMR 5293, F-33000, Bordeaux, France.
.
The PD-AGE international task force underscores the pivotal role that non-human
primate (NHP) models play in advancing our understanding of Parkinson’s disease
(PD) and ageing. Due to their close genetic, anatomical, and behavioural
similarity to humans, NHPs uniquely enable translational research to bridge
basic science towards clinical application. They are indispensable for modelling
the complex motor and non-motor symptoms of PD, as well as age-related
neurodegeneration. This paper outlines the scientific rationale, methodological
strengths, and ethical considerations surrounding NHP use in PD research. We
highlight the need for standardised models, innovative tools, and long-term
collaborative infrastructure to enhance the translational value of NHP studies.
We propose a three-phase roadmap to develop a global research consortium to
optimise resource use, improve model fidelity, and accelerate therapeutic
development for PD and related neurodegenerative disorders.
© 2025. The Author(s).
DOI: 10.1038/s41531-025-01088-8
PMCID: PMC12317990
PMID: 40753086
Conflict of interest statement: Competing interests: The authors declare no
competing interests.