Role of early life adversities in inflammation-related neuropsychiatric comorbidity in obesity.
Brain, Behavior, and Immunity. 2025-04-01; :
DOI: 10.1016/j.bbi.2025.04.039
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Montet J(1), Dexpert S(1), Darnaudéry M(1), Beau C(2), Forestier D(2),
Ledaguenel P(2), Magne E(2), Aouizerate B(3), Capuron L(4).
Author information:
(1)Univ. Bordeaux, INRAE, Bordeaux INP, NutriNeurO, UMR 1286, Bordeaux, France.
(2)Service de Chirurgie Digestive et Pariétale, Clinique Tivoli, 33000 Bordeaux,
and clinique Jean Villar, 33520 Bruges, France.
(3)Univ. Bordeaux, INRAE, Bordeaux INP, NutriNeurO, UMR 1286, Bordeaux, France;
CH Charles Perrens, Pôle de Psychiatrie Générale et Universitaire, Centre de
référence régional des pathologies anxieuses et dépressives, Centre Expert
Dépression Résistante FondaMental, Bordeaux, France.
(4)Univ. Bordeaux, INRAE, Bordeaux INP, NutriNeurO, UMR 1286, Bordeaux, France.
Electronic address: .
A growing body of data highlights the key role of adiposity-related inflammation
in the development of neuropsychiatric comorbidity on obesity. Nevertheless,
despite similar levels of inflammation, only a subgroup of obese subjects is
afflicted with neuropsychiatric symptoms, suggesting the contribution of
additional vulnerability factors. In light of previous work suggesting the
involvement of early life adversity (ELA), this study aims to determine whether
ELA promotes the emergence of inflammation-related neuropsychiatric symptoms in
a sample of obese subjects. Eighty-two adults afflicted with obesity
(BMI > 30 kg/m2) and twenty-one lean individuals (BMI