Influence of pro-obesogenic dietary habits on stress-induced cognitive alterations in healthy adult volunteers.
Neurobiology of Stress. 2021-11-01; 15: 100353
DOI: 10.1016/j.ynstr.2021.100353
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1. Neurobiol Stress. 2021 Jun 12;15:100353. doi: 10.1016/j.ynstr.2021.100353.
eCollection 2021 Nov.
Influence of pro-obesogenic dietary habits on stress-induced cognitive
alterations in healthy adult volunteers.
Delgado I(1), Dexpert S(1), Sauvant J(1), Cryan JF(2)(3), Capuron L(1).
Author information:
(1)Univ. Bordeaux, INRAE, Bordeaux INP, NutriNeuro, UMR 1286, F-33000, Bordeaux,
France.
(2)APC Microbiome Ireland, University College Cork, Cork, Ireland.
(3)Department of Anatomy & Neuroscience, University College Cork, Cork, Ireland.
Stress is a fundamental biological response that can be associated with
alterations in cognitive processes. Unhealthy dietary habits are proposed to
modulate this effect, notably through their pro-inflammatory potential. This
cross-sectional study aimed to evaluate the influence of an obesogenic dietary
pattern with inflammatory potential on stress-induced cognitive alterations in
healthy volunteers. Fifty healthy adult participants were stratified into two
diet groups: obesogenic vs. non-obesogenic, based on their self-reported
consumption of fat, sugar, and salt, assessed by the French National Program for
Nutrition and Health questionnaire and a food frequency questionnaire. Serum
high-sensitive C-reactive protein (hsCRP) was measured as a marker of systemic
inflammation using ELISA. Verbal memory and sustained attention were evaluated
through the Verbal Recognition Memory (VRM) test and the Rapid Visual
Information Processing (RVP) test respectively, from the Cambridge
Neuropsychological Test Automated Battery. Assessments were performed before and
after exposure to the psychological stressor Trier Social Stress Test (TSST).
Stress response was evaluated by subjective stress perception, salivary
cortisol, blood pressure, and heart rate. Twenty-two participants (44%)
presented an obesogenic diet. Systemic inflammation was significantly higher in
the obesogenic diet group (p=0.005). The TSST induced a significant stress
response, regardless of dietary habits (Time effect p