Intestinal gluconeogenesis is a key factor for early metabolic changes after gastric bypass but not after gastric lap-band in mice
Cell Metabolism. 2008-09-01; 8(3): 201-211
DOI: 10.1016/j.cmet.2008.08.008
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1. Cell Metab. 2008 Sep;8(3):201-11. doi: 10.1016/j.cmet.2008.08.008.
Intestinal gluconeogenesis is a key factor for early metabolic changes after
gastric bypass but not after gastric lap-band in mice.
Troy S(1), Soty M, Ribeiro L, Laval L, Migrenne S, Fioramonti X, Pillot B,
Fauveau V, Aubert R, Viollet B, Foretz M, Leclerc J, Duchampt A, Zitoun C,
Thorens B, Magnan C, Mithieux G, Andreelli F.
Author information:
(1)Institut National de la Sante et de la Recherche Medicale, U695, Faculté de
Médecine Xavier Bichat, Universite Paris 7, Paris, F-75870, France.
Comment in
Cell Metab. 2008 Sep;8(3):177-9. doi: 10.1016/j.cmet.2008.08.012.
Unlike the adjustable gastric banding procedure (AGB), Roux-en-Y gastric bypass
surgery (RYGBP) in humans has an intriguing effect: a rapid and substantial
control of type 2 diabetes mellitus (T2DM). We performed gastric lap-band (GLB)
and entero-gastro anastomosis (EGA) procedures in C57Bl6 mice that were fed a
high-fat diet. The EGA procedure specifically reduced food intake and increased
insulin sensitivity as measured by endogenous glucose production. Intestinal
gluconeogenesis increased after the EGA procedure, but not after gastric
banding. All EGA effects were abolished in GLUT-2 knockout mice and in mice with
portal vein denervation. We thus provide mechanistic evidence that the
beneficial effects of the EGA procedure on food intake and glucose homeostasis
involve intestinal gluconeogenesis and its detection via a GLUT-2 and
hepatoportal sensor pathway.
DOI: 10.1016/j.cmet.2008.08.008
PMID: 18762021 [Indexed for MEDLINE]