The novel non-hallucinogenic compound DM506 (3-methyl-1,2,3,4,5,6-hexahydroazepino[4,5-b]indole) induces sedative- and anxiolytic-like activity in mice by a mechanism involving 5-HT2A receptor activation
European Journal of Pharmacology. 2024-03-01; 966: 176329
DOI: 10.1016/j.ejphar.2024.176329
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Arias HR(1), Rudin D(2), Hines DJ(3), Contreras A(3), Gulsevin A(4), Manetti
D(5), Anouar Y(6), De Deurwaerdere P(7), Meiler J(8), Romanelli MN(5), Liechti
ME(2), Chagraoui A(9).
Author information:
(1)Department of Pharmacology and Physiology, Oklahoma State University College
of Osteopathic Medicine, Tahlequah, OK, USA.
(2)Divison of Clinical Pharmacology and Toxicology, Department of Pharmaceutical
Sciences, University of Basel, Basel, Switzerland; Division of Clinical
Pharmacology and Toxicology, Department of Biomedicine, University Hospital
Basel and University of Basel, Basel, Switzerland.
(3)Psychological and Brain Sciences, University of Nevada, Las Vegas, NV, USA.
(4)Department of Chemistry, Vanderbilt University, Nashville, TN, USA; Center
for Structural Biology, Vanderbilt University, Nashville, TN, USA.
(5)Department of Neurosciences, Psychology, Drug Research and Child Health
Section of Pharmaceutical and Nutraceutical Sciences, University of Florence,
Italy.
(6)UNIROUEN, Inserm U1239, Neuroendocrine, Endocrine and Germinal
Differentiation and Communication (NorDiC), Rouen Normandie University, 76000,
Mont-Saint-Aignan, France.
(7)Centre National de la Recherche Scientifique, Institut des Neurosciences
Integratives et Cognitives d’Aquitaine, UMR, 5287, Bordeaux, France.
(8)Institute for Drug Discovery, Leipzig University Medical School, 04103,
Leipzig, Germany.
(9)Department of Medical Biochemistry, Rouen University Hospital, CHU de Rouen,
France; UNIROUEN, Inserm U1239, Neuroendocrine, Endocrine and Germinal
Differentiation and Communication (NorDiC), Rouen Normandie University, 76000,
Mont-Saint-Aignan, France. Electronic address: .