Can brain neurons change identity? Lessons from obesity
Trends in Endocrinology & Metabolism. 2024-12-01; :
DOI: 10.1016/j.tem.2024.11.006
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1. Trends Endocrinol Metab. 2024 Dec 5:S1043-2760(24)00297-2. doi:
10.1016/j.tem.2024.11.006. Online ahead of print.
Can brain neurons change identity? Lessons from obesity.
Nicolas JC(1), Lee TH(1), Quarta C(2).
Author information:
(1)University of Bordeaux, INSERM, Neurocentre Magendie, U1215, F-33000,
Bordeaux, France.
(2)University of Bordeaux, INSERM, Neurocentre Magendie, U1215, F-33000,
Bordeaux, France. Electronic address: .
It has long been thought that the functional identity of mammalian brain neurons
is programmed during development and remains stable throughout adult life;
however, certain populations of neurons continue to express active regulators of
neuronal identity into adulthood. Prolonged exposure to diet-induced metabolic
stress induces features of neuronal identity modification in adult mice, and
maladaptive changes in neuronal identity maintenance have been linked to
cognitive impairment in humans suffering from neurodegenerative diseases often
associated with obesity. Here we discuss how, by unraveling the neurological
roots of obesity, we may solve the puzzle of whether mammalian brain neurons
retain identity plasticity into adulthood, while advancing knowledge of the
pathogenic mechanisms at the interface of metabolic and neurodegenerative
disorders.
Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.
DOI: 10.1016/j.tem.2024.11.006
PMID: 39643545
Conflict of interest statement: Declaration of interests No interests are
declared.