Plant extracts and omega-3 supplementation modulate hippocampal oxylipin profile in response to LPS-induced neuroinflammation.
Inflamm. Res.. 2024-09-28; 73(11): 2023-2042
DOI: 10.1007/s00011-024-01947-9
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Martin M(1)(2), Debenay E(1), Bardinet J(2)(3), Peltier A(1)(4), Pourtau L(2),
Gaudout D(2), Layé S(1), Pallet V(1), Dinel AL(1)(4), Joffre C(5).
Author information:
(1)Université Bordeaux, INRAE, Bordeaux INP, UMR 1286, Nutrineuro, Bordeaux,
33076, France.
(2)Activ’Inside, ZA du Grand Cazeau, 12 route de Beroy, Beychac-et-Caillau,
33750, France.
(3)Université Bordeaux, INSERM, BPH, Bordeaux, U1219, 33000, France.
(4)NutriBrain Research and Technology Transfer, NutriNeuro, Bordeaux, 33076,
France.
(5)Université Bordeaux, INRAE, Bordeaux INP, UMR 1286, Nutrineuro, Bordeaux,
33076, France. .
OBJECTIVE AND DESIGN: Neuroinflammation is a protective mechanism but can become
harmful if chronic and/or unregulated, leading to neuronal damage and cognitive
alterations. Limiting inflammation and promoting resolution could be achieved
with nutrients such as grapes and blueberries polyphenols, saffron carotenoids,
and omega-3, which have anti-inflammatory and proresolutive properties.
METHODS: This study explored the impact of 18-day supplementation with plant
extracts (grape, blueberry and saffron), omega-3 or both (mix) on
neuroinflammation induced by lipopolysaccharide (LPS, 250 µg/kg) in 149 mice at
different time points post-LPS treatment (30 min, 2 h, 6 h). Inflammatory,
oxidative and neuroprotective gene expression; oxylipin quantification; and
fatty acid composition were analyzed at each time point. PCA analysis was
performed with all these biomarkers.
RESULTS: Mix supplementation induced changes in the resolution of inflammation.
In fact, the production of proinflammatory mediators in the hippocampus started
earlier in the supplemented group than in the LPS group. Pro-resolving mediators
were also found in higher quantities in supplemented mice. These changes were
associated with increased hippocampal antioxidant status at 6 h post-LPS.
CONCLUSIONS: These findings suggest that such dietary interventions with plant
extracts, and omega-3 could be beneficial in preventing neuroinflammation and,
consequently, age-related cognitive decline. Further research is needed to
explore the effects of these supplements on chronic inflammation in the context
of aging.
© 2024. The Author(s).
DOI: 10.1007/s00011-024-01947-9
PMCID: PMC11541341
PMID: 39340661 [Indexed for MEDLINE]
Conflict of interest statement: Activ’Inside funds MM, JB, LP and DG. ED, SL,
VP, ALD, and CJ report no disclosures.