[Cognitive disorders in multiple sclerosis].
Revue Neurologique. 2007-06-01; 163(6-7): 697-702
DOI: 10.1016/s0035-3787(07)90482-8
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Brochet B(1), Bonnet M, Deloire M, Hamel D, Salort-Campana E.
Author information:
(1)Service de Neurologie, Hôpital Pellegrin, CHU de Bordeaux, 33076 Bordeaux
cedex, France.
Forty to sixty percent of patients with multiple sclerosis (MS) have cognitive
dysfunction. The frequency of cognitive disturbances according to the clinical
form is not completely understood and the natural history of these disorders has
not been extensively studied. Cognitive deficits can be detected in early stages
of the disease. Their frequency increases from clinically isolated syndromes, to
relapsing-remitting and secondary progressive MS. Cognitive abnormalities are
frequently observed also in primary progressive MS. The most frequently impaired
functions are information processing speed, attention and memory. Dementia is
uncommon but may disclose the disease. Diffuse cerebral injury, assessed by
magnetic resonance imaging, contributes to cognitive dysfunction in MS, probably
by interrupting connecting fibers between neuronal networks involved in these
cognitive functions. Compensatory mechanisms may occur at early stages but they
are limited by extension of brain injury.
DOI: 10.1016/s0035-3787(07)90482-8
PMID: 17607192 [Indexed for MEDLINE]