MRI predictors of cognitive outcome in early multiple sclerosis.

M.S.A. Deloire, A. Ruet, D. Hamel, M. Bonnet, V. Dousset, B. Brochet
Neurology. 2011-03-29; 76(13): 1161-1167
DOI: 10.1212/wnl.0b013e318212a8be

PubMed

Lire sur PubMed

1. Neurology. 2011 Mar 29;76(13):1161-7. doi: 10.1212/WNL.0b013e318212a8be.

Deloire MS(1), Ruet A, Hamel D, Bonnet M, Dousset V, Brochet B.

Author information:
(1)INSERM U 1049, University Victor Segalen, case 78, 146 rue Léo Saignat, 33076
Bordeaux cedex, France.

Erratum in
Neurology. 2012 Feb 21;78(8):608.

OBJECTIVE: To determine MRI predictors for cognitive outcome in patients with
early relapsing-remitting multiple sclerosis (MS).
METHODS: Forty-four patients recently diagnosed with clinically definite MS were
followed up with clinical and cognitive evaluations at 1, 2, 5, and 7 years and
underwent brain MRI including magnetization transfer (MT) imaging at baseline
and 2 years. Cognitive evaluation was also performed in 56 matched healthy
subjects at baseline. Cognitive testing included the Brief Repeatable Battery.
Imaging parameters included lesion load, brain parenchymal fraction (BPF),
ventricular fraction (VF), and mean MT ratio (MTR) of lesion and
normal-appearing brain tissue (NABT) masks.
RESULTS: At baseline, patients presented deficits of memory, attention, and
information processing speed (IPS). Over 2 years, all magnetic resonance
parameters deteriorated significantly. Over 7 years, Expanded Disability Status
Scale score deteriorated significantly. Fifty percent of patients deteriorated
on memory cognitive domain and 22.7%of patients on IPS domain. Seven-year change
of memory scores was significantly associated with baseline diffuse brain damage
(NABT MTR). IPS z score change over 7 years was correlated with baseline global
atrophy (BPF), baseline diffuse brain damage, and central brain atrophy (VF)
change over 2 years.
CONCLUSION: The main predictors of cognitive changes over 7 years are baseline
diffuse brain damage and progressive central brain atrophy over the 2 years
after MS diagnosis.