Information processing speed impairment and cerebellar dysfunction in relapsing-remitting multiple sclerosis.

Aurélie Ruet, Delphine Hamel, Mathilde S.A. Deloire, Julie Charré-Morin, Aurore Saubusse, Bruno Brochet
Journal of the Neurological Sciences. 2014-12-01; 347(1-2): 246-250
DOI: 10.1016/j.jns.2014.10.008

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1. J Neurol Sci. 2014 Dec 15;347(1-2):246-50. doi: 10.1016/j.jns.2014.10.008.
Epub 2014 Oct 12.

Information processing speed impairment and cerebellar dysfunction in
relapsing-remitting multiple sclerosis.

Ruet A(1), Hamel D(2), Deloire MS(1), Charré-Morin J(1), Saubusse A(1), Brochet
B(3).

Author information:
(1)Service de Neurologie, CHU de Bordeaux, F-33076 Bordeaux, France; INSERM-CHU
CIC-P 0005, CHU de Bordeaux, F-33076 Bordeaux, France.
(2)Neurocentre Magendie, INSERM U862, Université de Bordeaux, F-33076 Bordeaux,
France; Translational Research and Advanced Imaging Laboratory (TRAIL) cluster
of excellence, Université de Bordeaux, F-33076 Bordeaux, France.
(3)Service de Neurologie, CHU de Bordeaux, F-33076 Bordeaux, France; INSERM-CHU
CIC-P 0005, CHU de Bordeaux, F-33076 Bordeaux, France; Neurocentre Magendie,
INSERM U862, Université de Bordeaux, F-33076 Bordeaux, France; Translational
Research and Advanced Imaging Laboratory (TRAIL) cluster of excellence,
Université de Bordeaux, F-33076 Bordeaux, France. Electronic address:
.

OBJECTIVE: The aim of this work is to study the relationship between information
processing speed (IPS) impairment and motor testing that reflects cerebellar
function in persons with multiple sclerosis (PwMS).
METHODS: 60 persons with relapsing-remitting multiple sclerosis with a mean
disease duration of 4.2 ± 4 years were studied cross-sectionally. Motor
cerebellar functioning was studied using the Nine-Hole Peg Test (NHPT) and the
Kurtzke Functional Status Scales, and several cognitive domains were evaluated
(IPS, working memory, episodic memory, attention, executive function).
Correlations between the global NHPT score and neuropsychological test scores or
impairment in each cognitive domain were studied using univariate and
multivariate analyses.
RESULTS: The NHPT and a test of IPS significantly differentiated PwMS with and
without cerebellar impairment. The NHPT total score was correlated with measures
of IPS. Multivariate analyses showed a correlation between the NHPT and measures
of IPS, but not between the NHPT and other neuropsychological tests that did not
have a speed component.
CONCLUSION: In this sample of PwMS, motor cerebellar impairment assessed by the
NHPT was correlated with IPS impairment.