Deciphering Depressive Mood in Relapsing-Remitting and Progressive Multiple Sclerosis and Its Consequence on Quality of Life.
PLoS ONE. 2015-11-10; 10(11): e0142152
DOI: 10.1371/journal.pone.0142152
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1. PLoS One. 2015 Nov 10;10(11):e0142152. doi: 10.1371/journal.pone.0142152.
eCollection 2015.
Deciphering Depressive Mood in Relapsing-Remitting and Progressive Multiple
Sclerosis and Its Consequence on Quality of Life.
Lamargue Hamel D(1), Deloire M(2), Ruet A(1)(2), Charré-Morin J(2), Saubusse
A(2), Ouallet JC(2), Brochet B(1)(2).
Author information:
(1)INSERM U.862, Neurocentre Magendie, Université de Bordeaux, Bordeaux, France.
(2)INSERM-CHU CIC-P 0005, & Service de Neurologie, CHU de Bordeaux, F-33076,
Bordeaux, France.
BACKGROUND: Depressive mood and other emotional symptoms are common in multiple
sclerosis (MS). The patient-reported outcome version of the « Echelle d’Humeur
Dépressive » (EHD-PRO) aims to differentiate between two dimensions of depressive
mood in people living with MS (PwMS).
OBJECTIVES: First, to compare EHD-PRO assessment and its two dimensions, lack of
emotional control and emotional blunting, between a large sample of healthy
controls (HCs) and two samples of PwMS, relapsing-remitting MS (RRMS) and
primary progressive MS (PPMS); and second, to analyse the relationships between
EHD-PRO scores with neurological disability, cognitive function, fatigue and
health-related quality of life (HR-QOL).
RESULTS: Regardless of their phenotype, PwMS had significantly higher EHD-PRO
scores than HCs. EHD-PRO scores did not differ between the two MS groups.
EHD-PRO scores did not correlate with disability and fatigue scores, disease
duration or cognitive z scores. In RRMS, the lack of emotional control was
independently associated with a decrease in HR-QOL.
CONCLUSION: The EHD-PRO is able to easily detect depressive mood and to
differentiate between two clinical dimensions, emotional blunting and lack of
emotional control. The scale is sensitive and seems robust to confounding
factors. Lack of emotional control seems to contribute significantly to altered
HR-QOL in RRMS.
DOI: 10.1371/journal.pone.0142152
PMCID: PMC4640551
PMID: 26555230 [Indexed for MEDLINE]
Conflict of interest statement: Competing Interests: The study was funded by
Bayer Health Care (CSCT Study). This does not alter the authors’ adherence to
PLOS ONE policies on sharing data and materials. The authors declare that they
have nothing else to disclose in relation with this study.