Cerebellar Assessment in Early Multiple Sclerosis.
Cerebellum. 2016-11-04; 16(2): 607-611
DOI: 10.1007/s12311-016-0831-8
Lire sur PubMed
1. Cerebellum. 2017 Apr;16(2):607-611. doi: 10.1007/s12311-016-0831-8.
Cerebellar Assessment in Early Multiple Sclerosis.
Moroso A(1)(2)(3), Ruet A(1)(2)(3), Deloire M(1), Lamargue-Hamel D(2)(3),
Cubizolle S(1), Charré-Morin J(1), Saubusse A(1), Brochet B(4)(5)(6).
Author information:
(1)CHU de Bordeaux, INSERM-CHU CIC-P 0005, & Service de Neurologie, F-33076,
Bordeaux, France.
(2)Université de Bordeaux, F-33076, Bordeaux, France.
(3)Neurocentre Magendie, INSERM U1215, F-33077, Bordeaux, France.
(4)CHU de Bordeaux, INSERM-CHU CIC-P 0005, & Service de Neurologie, F-33076,
Bordeaux, France. .
(5)Université de Bordeaux, F-33076, Bordeaux, France.
.
(6)Neurocentre Magendie, INSERM U1215, F-33077, Bordeaux, France.
.
Cerebellar impairment is frequent and predictive of disability in multiple
sclerosis (MS). The Nine-Hole Peg Test (NHPT) is commonly used to assess
cerebellar symptoms despite its lack of specificity for cerebellar ataxia.
Eye-tracking is a reliable test for identifying subtle cerebellar symptoms and
could be used in clinical trials, including those involving early MS patients.
To evaluate, by the use of eye-tracking, the accuracy of the NHPT in detecting
subtle cerebellar symptoms in patients with clinically isolated syndrome with a
high risk of conversion to MS (HR-CIS). Twenty-nine patients and 13 matched
healthy controls (HC) underwent an eye-tracking protocol. Cerebellar impairment
was defined by registration of saccadic intrusions or at least 10 % dysmetria in
a saccadic movement recording. These criteria were compared to NHPT performance.
Sixteen patients fulfilled saccadic criteria for cerebellar impairment. NHPT
performance was significantly increased in HR-CIS patients (p