Effect of cognitive rehabilitation on neuropsychological and semiecological testing and on daily cognitive functioning in multiple sclerosis: The REACTIV randomized controlled study.
Journal of the Neurological Sciences. 2020-08-01; 415: 116929
DOI: 10.1016/j.jns.2020.116929
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1. J Neurol Sci. 2020 Aug 15;415:116929. doi: 10.1016/j.jns.2020.116929. Epub
2020 May 20.
Effect of cognitive rehabilitation on neuropsychological and semiecological
testing and on daily cognitive functioning in multiple sclerosis: The REACTIV
randomized controlled study.
Lamargue D(1), Koubiyr I(1), Deloire M(2), Saubusse A(2), Charre-Morin J(2),
Moroso A(2), Coupé P(3), Brochet B(4), Ruet A(5).
Author information:
(1)Univ. Bordeaux, F-33000 Bordeaux, France; Inserm U1215 – Neurocentre
Magendie, F-33000 Bordeaux, France.
(2)CHU de Bordeaux, F-33000 Bordeaux, France.
(3)Laboratoire Bordelais de Recherche en Informatique, UMR CNRS 5800, PICTURA,
F-33405 Talence, France.
(4)Univ. Bordeaux, F-33000 Bordeaux, France; Inserm U1215 – Neurocentre
Magendie, F-33000 Bordeaux, France; CHU de Bordeaux, F-33000 Bordeaux, France.
Electronic address: .
(5)Univ. Bordeaux, F-33000 Bordeaux, France; Inserm U1215 – Neurocentre
Magendie, F-33000 Bordeaux, France; CHU de Bordeaux, F-33000 Bordeaux, France.
BACKGROUND: Specific cognitive rehabilitation (SCR) has been suggested for
multiple sclerosis (MS). A randomized controlled trial (RCT) evaluating the
therapeutic effects of SCR is necessary.
OBJECTIVE: To demonstrate the superiority of a SCR program (REACTIV) over
nonspecific intervention (NSI) for neuropsychological (NP) assessment, virtual
reality (VR) cognitive testing and daily cognitive functioning.
METHODS: A single-blind RCT compared SCR and NSI in patients with MS with
cognitive complaint. Both programs included 50 individual sessions, 3 times a
week for 17 weeks in a real-world setting. The primary end-point was NP
assessment. Secondary end-points included semiecological VR tasks (Urban Daily
Cog®) and daily cognitive functioning assessment. Maintenance of the effects at
8 months was studied.
RESULTS: Of the 35 patients, 18 completed the SCR, and 17 completed the NSI.
Several NP and semiecological scores improved significantly more after SCR than
after NSI. More NP scores improved significantly after SCR than after NSI. SCR
improved daily cognitive functioning. Most improvements were maintained at
8 months.
CONCLUSION: SCR performed in a real-world setting is superior to NSI for
improving performance in specific cognitive domains and information processing
speed, and for improving cognitive functioning, as evaluated by ecological tools
close to daily life and a daily cognitive functioning questionnaire.
Copyright © 2020 Elsevier B.V. All rights reserved.
DOI: 10.1016/j.jns.2020.116929
PMID: 32460145 [Indexed for MEDLINE]
Conflict of interest statement: Declaration of Competing Interest None.