Safety and effects of a therapeutic 15 Hz rTMS protocol administered at different suprathreshold intensities in able-bodied individuals

Nabila Brihmat, Didier Allexandre, Mehmed B. Bayram, Soha Saleh, Xiaofei Guan, Guang H. Yue, Jian Zhong, Gail F. Forrest
Journal of Neurophysiology. 2023-01-01; 129(1): 56-65
DOI: 10.1152/jn.00268.2022

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The results of this pilot study show the effects of a therapeutically promising 15 Hz repetitive transcranial magnetic stimulation (rTMS) protocol, administered at different suprathreshold intensities in able-bodied individuals. Although tolerable and feasible with a neuromodulatory potential, 15 Hz rTMS might result in persistent excitability that needs to be closely monitored if administered at suprathreshold stimulation intensity. These results reaffirm the importance of feasibility studies, especially in translational animal-to-human research.