Insights into COVID-19 pathophysiology from a longitudinal multisystem report during acute infection
Experimental Neurology. 2024-10-01; 380: 114917
DOI: 10.1016/j.expneurol.2024.114917
Lire sur PubMed
1. Exp Neurol. 2024 Oct;380:114917. doi: 10.1016/j.expneurol.2024.114917. Epub
2024 Aug 9.
Insights into COVID-19 pathophysiology from a longitudinal multisystem report
during acute infection.
Brihmat N(1), Bayram MB(2), Bheemreddy A(3), Saleh S(4), Yue GH(5), Forrest
GF(6).
Author information:
(1)Tim and Caroline Reynolds Center for Spinal Stimulation, Kessler Foundation,
West Orange, NJ, United States; Department of Physical Medicine and
Rehabilitation, Rutgers – New Jersey Medical School, Newark, NJ, United States.
Electronic address: .
(2)Tim and Caroline Reynolds Center for Spinal Stimulation, Kessler Foundation,
West Orange, NJ, United States; Department of Physical Medicine and
Rehabilitation, Rutgers – New Jersey Medical School, Newark, NJ, United States.
(3)Tim and Caroline Reynolds Center for Spinal Stimulation, Kessler Foundation,
West Orange, NJ, United States.
(4)Department of Rehabilitation and Movement Sciences, Rutgers School of Health
Professions, Newark, NJ, United States; Department of Neurology, Robert Wood
Johnson Medical School (RWJMS), New Brunswick, NJ, United States.
(5)Department of Physical Medicine and Rehabilitation, Rutgers – New Jersey
Medical School, Newark, NJ, United States; Center for Mobility and
Rehabilitation Engineering Research, Kessler Foundation, West Orange, NJ, United
States.
(6)Tim and Caroline Reynolds Center for Spinal Stimulation, Kessler Foundation,
West Orange, NJ, United States; Department of Physical Medicine and
Rehabilitation, Rutgers – New Jersey Medical School, Newark, NJ, United States;
Center for Mobility and Rehabilitation Engineering Research, Kessler Foundation,
West Orange, NJ, United States. Electronic address:
.
The Coronavirus disease 2019 (COVID-19), an illness caused by a SARS-CoV-2 viral
infection, has been associated with neurological and neuropsychiatric disorders,
revealing its impact beyond the respiratory system. Most related research
involved individuals with post-acute or persistent symptoms of COVID-19, also
referred to as long COVID or Post-Acute Sequelae of COVID-19 (PASC). In this
longitudinal unique report, we aimed to describe the acute supraspinal and
corticospinal changes and functional alterations induced by a COVID-19 infection
using neuroimaging, neurophysiological and clinical assessment of a participant
during acute infection, as compared to three other visits where the participant
had no COVID-19. The results favor a multisystem impairment, impacting cortical
activity, functional connectivity, and corticospinal excitability, as well as
motor and cardiovascular function. The report suggests pathophysiological
alteration and impairment already present at the acute stage, that if resolved
tend to lead to a full clinical recovery. Such results could be also insightful
into PASC symptomatology.
Copyright © 2024. Published by Elsevier Inc.
DOI: 10.1016/j.expneurol.2024.114917
PMID: 39127120 [Indexed for MEDLINE]
Conflict of interest statement: Declaration of competing interest The authors
declare having no conflict of interest.