The Neuroendocrinology of the Microbiota-Gut-Brain Axis: A Behavioural Perspective
Frontiers in Neuroendocrinology. 2018-10-01; 51: 80-101
DOI: 10.1016/j.yfrne.2018.04.002
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1. Front Neuroendocrinol. 2018 Oct;51:80-101. doi: 10.1016/j.yfrne.2018.04.002.
Epub 2018 May 16.
The Neuroendocrinology of the Microbiota-Gut-Brain Axis: A Behavioural
Perspective.
Cussotto S(1), Sandhu KV(2), Dinan TG(3), Cryan JF(4).
Author information:
(1)APC Microbiome Ireland, University College Cork, Cork, Ireland; Department of
Anatomy and Neuroscience, University College Cork, Cork, Ireland.
(2)APC Microbiome Ireland, University College Cork, Cork, Ireland.
(3)APC Microbiome Ireland, University College Cork, Cork, Ireland; Department of
Psychiatry and Neurobehavioural Science, University College Cork, Cork, Ireland.
(4)APC Microbiome Ireland, University College Cork, Cork, Ireland; Department of
Anatomy and Neuroscience, University College Cork, Cork, Ireland. Electronic
address: .
The human gut harbours trillions of symbiotic bacteria that play a key role in
programming different aspects of host physiology in health and disease. These
intestinal microbes are also key components of the gut-brain axis, the
bidirectional communication pathway between the gut and the central nervous
system (CNS). In addition, the CNS is closely interconnected with the endocrine
system to regulate many physiological processes. An expanding body of evidence
is supporting the notion that gut microbiota modifications and/or manipulations
may also play a crucial role in the manifestation of specific behavioural
responses regulated by neuroendocrine pathways. In this review, we will focus on
how the intestinal microorganisms interact with elements of the host
neuroendocrine system to modify behaviours relevant to stress, eating behaviour,
sexual behaviour, social behaviour, cognition and addiction.
Copyright © 2018 Elsevier Inc. All rights reserved.
DOI: 10.1016/j.yfrne.2018.04.002
PMID: 29753796 [Indexed for MEDLINE]