Moderate stress enhances memory persistence: Are adrenergic mechanisms involved?
Behavioral Neuroscience. 2012-01-01; 126(5): 729-734
DOI: 10.1037/a0029861
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Parfitt GM(1), Barbosa ÂK, Campos RC, Koth AP, Barros DM.
Author information:
(1)Laboratório de Neurociências, Instituto de Ciências Biológicas, Universidade
Federal do rio Grande(FURG), Rio Grande, Brazil.
Memory persistence in the inhibitory avoidance (IA) task has been recently shown
to require a new event of consolidation 12 hr after acquisition. The
immobilization stress (IS) model is largely used to study the effects of stress
on memory. In this study we investigated the interactions between stress by
immobilization and its effect on the persistence of memory, and also a possible
effect mediated by β-adrenergic modulation of stress on memory persistence. An
enhancement of long-term memory (LTM) persistence caused by stress through
immobilization applied 12 hr after IA training was observed when the animals
were submitted to 15 min or 1 hr of IS, but not to 3 hr. The reversal of this
memory enhancement caused by IS was observed when the β-adrenergic antagonist
propranolol was infused intraperitoneally prior to stress, which implies that
β-adrenergic receptors are involved in stress enhancement of LTM persistence.
PsycINFO Database Record (c) 2012 APA, all rights reserved.
DOI: 10.1037/a0029861
PMID: 23025835 [Indexed for MEDLINE]