Dietary n-3 polyunsaturated fatty acid deprivation together with early maternal separation increases anxiety and vulnerability to stress in adult rats.
Prostaglandins, Leukotrienes and Essential Fatty Acids. 2011-09-01; 85(3-4): 129-136
DOI: 10.1016/j.plefa.2011.07.001
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Mathieu G(1), Oualian C, Denis I, Lavialle M, Gisquet-Verrier P, Vancassel S.
Author information:
(1)INRA, Unité de Nutrition et Régulation Lipidiques des Fonctions Cérébrales,
NuRéLiCe, UR909, Domaine de Vilvert, Jouy en Josas F-78352, France.
Low concentrations of n-3 polyunsaturated fatty acid (PUFA) and chronic stress
are implicated in susceptibility to mood disorders. We have investigated the
combined effects of chronic n-3 PUFA dietary deficiency and early maternal
separation (MS) stress on the reactivity to stressful situations of rats as
adults. Pups fed a control or an n-3 PUFA deficient diet were daily separated
for two weeks before weaning They were all tested at 3 month-old to determine
their anxiety, and their ability to learn two aversive tasks differing in the
control they could exert on the situation: auditory fear conditioning and
brightness avoidance discrimination. Neither the n-3 PUFA-deficient diet nor MS
alone significantly affected behavior. But n-3 PUFA-deficient rats that had been
separated were more anxious and fearful in inescapable situations, while their
ability to cope with an aversive avoidance task remained unaffected. These
results support the notion that PUFA-unbalanced diet, together with stress, may
be a determinant risk factor in emotional disorders.
Copyright © 2011 Elsevier Ltd. All rights reserved.
DOI: 10.1016/j.plefa.2011.07.001
PMID: 21784625 [Indexed for MEDLINE]