Amyotrophic Lateral Sclerosis (ALS) and extremely-low frequency (ELF) magnetic fields: A study in the SOD-1 transgenic mouse model
Amyotrophic Lateral Sclerosis. 2009-01-01; 10(5-6): 370-373
DOI: 10.3109/17482960802320396
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Poulletier de Gannes F(1), Ruffié G, Taxile M, Ladevèze E, Hurtier A, Haro E,
Duleu S, Charlet de Sauvage R, Billaudel B, Geffard M, Veyret B, Lagroye I.
Author information:
(1)University of Bordeaux 1, IMS laboratory, Bioelectromagnetics group, ENSCPB,
16 Avenue Pey Berland, Pessac, France.
There is some evidence from epidemiological studies of an association between
occupational exposure to electromagnetic fields and Amyotrophic Lateral
Sclerosis (ALS). Our aim was to perform, for the first time, an animal study in
a controlled magnetic environment. We used the SOD-1 mouse model to assess the
possible effect of ELF magnetic fields on development of the disease. Seven mice
per group were exposed to 50 Hz magnetic fields at two intensities (100 and 1000
microT(rms)) before the onset of the clinical signs of ALS. Exposure lasted 7
weeks, and body weight, motor performance and life span were monitored. Our
results did not reveal any evidence of a link between ELF exposure and ALS in
this transgenic animal model.