Neural network involved in time perception: An fMRI study comparing long and short interval estimation
Hum. Brain Mapp.. 2005-01-01; 25(4): 433-441
DOI: 10.1002/hbm.20126
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Pouthas V(1), George N, Poline JB, Pfeuty M, Vandemoorteele PF, Hugueville L,
Ferrandez AM, Lehéricy S, Lebihan D, Renault B.
Author information:
(1)Unité de Neurosciences Cognitives et Imagerie Cérébrale, Hôpital de la
Salpêtrière, Paris, France.
In this study, long ( approximately 1,300 ms) and short duration ( approximately
450 ms) estimation trials in an event-related functional MRI (fMRI) study were
contrasted in order to reveal the regions within a time estimation network
yielding increased activation with the increase of the duration to be estimated.
In accordance with numerous imaging studies, our results showed that the
presupplementary motor area (preSMA), the anterior cingulate, the prefrontal and
parietal cortices, and the basal ganglia were involved in the estimation trials
whatever the duration to be estimated. Moreover, only a subset of the regions
within this distributed cortical and subcortical network yielded increased
activation with increasing time, namely, the preSMA, the anterior cingulate
cortex, the right inferior frontal gyrus (homolog to Broca’s area), the
bilateral premotor cortex, and the right caudate nucleus. This suggests that
these regions are directly involved in duration estimation. We propose that the
caudate-preSMA circuit, the anterior cingulate, and the premotor-inferior
frontal regions may support a clock mechanism, decision and response-related
processes, and active maintenance of temporal information, respectively.
DOI: 10.1002/hbm.20126
PMCID: PMC6871738
PMID: 15852471 [Indexed for MEDLINE]