Structural insights into fusion mechanisms of small extracellular vesicles with model plasma membranes

Fabio Perissinotto, Valeria Rondelli, Beatrice Senigagliesi, Paola Brocca, László Almásy, László Bottyán, Dániel Géza Merkel, Heinz Amenitsch, Barbara Sartori, Karin Pachler, Magdalena Mayr, Mario Gimona, Eva Rohde, Loredana Casalis, Pietro Parisse
Nanoscale. 2021-01-01; 13(10): 5224-5233
DOI: 10.1039/d0nr09075a

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Extracellular vesicles exert their function through specific interaction with cell membrane. Through atomic force microscopy, neutron scattering and reflectometry we highlight a process deviating from simple fusion, driven by phase boundaries.