It takes two to tango: Concerted protein translation and degradation necessary for synaptic scaling
Ana Luisa Carvalho, Dominique Fernandes
PLoS Biol. 2021-11-24; 19(11): e3001448
DOI: 10.1371/journal.pbio.3001448
Lire sur PubMed
PLoS Biol. 2021-11-24; 19(11): e3001448
DOI: 10.1371/journal.pbio.3001448
Lire sur PubMed
Carvalho AL(1)(2), Fernandes D(1)(3).
Author information:
(1)CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.
(2)Department of Life Sciences, University of Coimbra, Coimbra, Portugal.
(3)Institute of Interdisciplinary Research, University of Coimbra, Coimbra, Portugal.
Comment on
PLoS Biol. 2021 Nov 23;19(11):e3001432.
Synaptic scaling allows neurons to adjust synaptic strength in response to
chronic alterations in neuronal activity. A new study in PLOS Biology identifies
a pathway that synergizes protein synthesis and degradation with remodeling of
the microRNA (miRNA)-induced silencing complex (miRISC) to mediate synaptic
scaling.