Venue: Centre Broca
Anne-Noël Samaha
Université de Montréal
https://fr.samaha-lab.com/
Invited by Claudia Fornari and Céline Nicolas (INCIA)
Title
On Modelling Cocaine Addiction in Rats
Abstract
A widely used preclinical procedure to study features of cocaine addiction involves allowing laboratory animals to take drug continuously, for hours each day. However, data in human cocaine users suggest that cocaine use may typically be intermittent, rather than continuous. Here I will present surprising findings concerning the effects of intermittent versus continuous cocaine intake in rats. As it turns out, less is more, and intermittent cocaine use is especially effective in producing addiction-relevant patterns of cocaine seeking and taking.
Selected publications
Amphetamine maintenance therapy during intermittent cocaine self-administration in rats attenuates psychomotor and dopamine sensitization and reduces addiction-like behavior. Florence Allain, Benoît Delignat-Lavaud, Marie-Pierre Beaudoin, Vincent Jacquemet, Terry.E Robinson Louis-Eric Trudeau and Anne-Noël Samaha. Neuropsychopharmacology, 2021
The transition to cocaine addiction: the importance of pharmacokinetics for preclinical models. Alex B. Kawa, Florence Allain, Terry E. Robinson and Anne-Noël Samaha. Psychopharmacology, 2019
Revisiting long-access versus short-access cocaine self-administration in rats: intermittent intake promotes addiction symptoms independent of session length. Florence Allain and Anne-Noël Samaha. Addiction Biology, 2018
High and escalating levels of cocaine intake are dissociable from subsequent incentive motivation for the drug in rats. Florence Allain, Karim Bouayad-Gervais and Anne-Noël Samaha. Psychopharmacology, 2018
How fast and how often: The pharmacokinetics of drug use are decisive in addiction. Florence Allain, Ellie-Anna Minogianis, David C.S. Roberts and Anne-Noël Samaha. Neuroscience and Biobehavioral Reviews, 2015.