Call for proposals 2025 : Identifying new therapeutic molecules for rare diseases
Expire le 4 septembre 2025
This call aims to support scientific research projects focused on identifying new molecules with potential for therapeutic application, with the goal of developing innovative treatments for individuals living with rare diseases. To achieve this objective, the call will support projects addressing one or more of the following key stages of the drug discovery pipeline:
- High-Content/High-Throughput Screening (HCS/HTS)
HCS or HTS methodologies using chemical libraries to identify biologically active compounds (« hits ») with potential therapeutic relevance. - In vitro mechanistic screening
Detailed in vitro investigation of specific signalling pathways, to validate and further characterize targeted pathways and potential hits identified through previous broad screening efforts. - Hit-to-Lead optimization
Refining and optimizing hit compounds to improve their pharmacological properties and drug- like profiles, thereby advancing them toward lead compound status