Venue: BBS
Kyriaki Sidiropoulou
Professor of Neurophysiology
Department of Biology at the University of Crete
Invited by Mathieu Wolff (INCIA)
Title
The role of prefrontal cortex development in the emergence of cognitive symptoms in schizophrenia: Insights from the MAM mouse model
Abstract
The prefrontal cortex is characterized by protracted development that lasts until adulthood. My lab has contributed to this by investigating the intrinsic and synaptic properties of PFC pyramidal neurons and GABAergic interneurons from the neonatal stage to adulthood, along with investigations of cognitive function that depends on the prefrontal cortex. We have identified that intrinsic properties of pyramidal neurons primarily mature in the first 3 postnatal weeks, the intrinsic properties of parvalbumin and somatostatin interneurons continue their maturation to adolescence while the synaptic properties, excitatory and inhibitory, continue to change until adulthood. Given this developmental scaffold for PFC neural circuit properties, we investigate the adaptations of PFC synaptic properties in animal models of schizophrenia throughout development and test developmental specific interventions that allow for rescue of cognitive deficits. In the talk, I will also refer to recent synergies with the group of Mathieu Wolff.