Unité neuro-vasculaire Archives - Bordeaux Neurocampus

Dynamics of neuronal and non neuronal networks underlying memory processing (MEMORY)

Susanna Pietropaolo — Thu, 07 Jun 2018 16:10:22 +0000

Our team aims at elucidating the spatio-temporal evolution of memory traces and the cerebral vascular organization associated with memory, in health and disease. The team has made important breakthroughs in identifying early tagging of cortical networks required for the formation of enduring associative memory. We also identified molecular mechanisms involved in memory, including molecular tags and the interaction of CaMKII with NR2B receptors. Currently, our research mainly focuses on: 1- understanding the functional contributions of NMDA receptors subtypes and its molecular partners, 2- deciphering the role of the vascular networks in the stabilization of remote memories during the course of…

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Pathophysiology of neuron-oligodendrocyte interactions

Battefeld Arne — Mon, 07 Jan 2019 17:47:30 +0000

Bidirectional neuron-glia interactions provide the framework for the organization of the brain. One type of glia cell, the oligodendrocyte is well known for the establishment of myelin sheaths around axons, the neuronal output structure. Myelin enables fast communication between neurons, but oligodendrocytes fulfill additional physiological functions which we only start to understand. Our research aims to address this knowledge gap by understanding the physiology of oligodendrocytes and their impact on neuronal communication and vice-versa. We address our research questions on the single cell and micro-circuit level. Alterations of oligodendrocytes are a common feature among several neurodegenerative diseases. By combining our…

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